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in a murine model and to identify the NCS‐382 metabolites formed by mouse and human. NCS‐382 single‐dose mouse pharmacokinetics were established following an intraperitoneal injection (100, 300, and 500 mg/kg ...
method for simultaneous determination of the oxidative metabolites of eight probe substrates for hepatic CYPs. The modulatory effects of HSYW on the oxidative metabolism of apatinib were investigated ...
PubMed WorldCat S. Sarda , C. Page, K. Pickup, T. Schulz-Utermoehl and I. Wilson, Diclofenac metabolism in the mouse : Novel in vivo metabolites identified by high performance liquid chromatography coupled ...
and serosal layers and differences in metabolism due to the route of administration are addressed. Administration of the metabolite may or may not directly reflect the toxicity associated with drug use. However ...
are formed by oxidative metabolism of parent PBDEs in vivo . Hepatic biotransformation catalyzed by cytochrome P450 (CYP) enzymes is the major pathway for the formation of hydroxylated metabolites of lipophilic ...
of hepatoma cell lines in drug development; however, these cells normally contain low levels of metabolizing enzymes and usually poorly reflect human hepatocytes in vivo [1]. Developing hepatocytes from other ...
or the oral model, despite the fact that AMAP is also metabolized . Metabolites of AMAP and APAP have been shown to bind to different proteins in hepatocytes, with APAP derivatives binding to mitochondrial ...
Search ADS PubMed WorldCat 11 Riley RJ , Roberts P, Coleman MD, Kitteringham NR, Park BK. Bioactivation of dapsone to a cytotoxic metabolite : in vitro use of a novel two compartment system which contains ...
increase in the amplitude of whole-cell currents carried by KV7.2/3 channels heterologously expressed in Chinese hamster ovary (CHO) cells.[46] Diclofenac opens KV7 channels in the mouse olfactory bulb.[81 ...
chemical inhibitors and recombinant human CYPs were used to confirm that the CYPs contributed to the metabolism of NAF enantiomers. Key findings Three metabolites were found and characterized in the HLMs ...
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