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(IONPs) as a model system, we investigated the effect of core size and PEG molecule weights on in vivo distribution in mice. Three PEGylated IONPs, including 14 nm IONP@PEG2,000, 14 nm IONP@PEG5,000 ...
degrees of modification. Our structure-dependent reactivity model was also able to simulate PEGylation progress curves and estimate “PEGmer” distribution with accurate predictions across different proteins ...
of photosensitizers in general enhances their water-solubility and tumor cell accumulation. A series of pegylated di-cationic ZnPcs were synthesized from conjugation of a low molecular weight PEG group to a pre-formed ...
dimer is composed of two rhTNFbp molecules ( molecular weight 18,278 daltons each) joined by polyethylene glycol 2000 (PEG2010. The steady state distribution volume of rhTNFbp-PEG20K was 55 ml/kg and 359 ...
that determine the effect of PEGylation on the bio‐ and physicochemical activity of modified compounds encompass the number of attached PEGs, the molecular weight and architecture (linear or branched) of the PEG ...
Administration route dependency on the distribution of PEGylated recombinant human tumor necrosis factor binding protein (rhTNFbp-PEG20K dimer) was observed following a subcutaneous (sc ...
‐hydroxyethyl methacrylate (HEMA), vinyl end functionalized poly(lactic acid) macromonomers (HEMA‐LAn) have been produced with tunable number of lactic acid units (larger than 5) and a low molecular weight ...
of paramagnetic biotinylated liposomes from the blood circulation in C57BL/6 mice. Avidin‐induced alterations in blood clearance kinetics and tissue distribution were studied quantitatively by determination ...
Background Poly(ethylene imine) (PEI) is a widely used transfection reagent for mammalian cells, but in vivo application of PEI 25 kDa is restricted by its toxicity. Low molecular weight (LMW) PEI ...
of PEGylation significantly prolong the circulating lifetime of the modified peptide and protein drugs. Higher the number and the molecular weight of PEG chains attached, the better is the foregoing protection ...
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