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-old female mice were isolated and cultured for 10 days in serum-free media in the absence or presence of IGF-I (100 nM) ( anabolic stimulation) or OSM (10 ng/mL) + TNF-α (20 ng/mL) ( catabolic stimulation ...
Chondrocytes, the only cell type present in articular cartilage, regulate tissue homeostasis by a fine balance of metabolism that includes both anabolic and catabolic activities. Therefore ...
and the ERK pathway was blocked using a selective molecule‐based inhibitor U0126. Gene expression of catabolic and anabolic markers , proinflammatory, and NPCs markers was investigated. The enzymatic activity ...
and the ability to resist compressive forces, respectively (Hardingham and Fosang, 1992 ). Chondrocytes maintain the metabolic homeostasis of cartilage by balanced anabolic and catabolic activities. During ...
wild‐type (Wt) littermates, reduced levels of matrix proteoglycan (PG) and aggrecan were seen in discs of 23‐month old PAPPA−/− mice. Decreased aggrecanolysis and expression of two key catabolic markers ...
environment. We tested a series of anabolic and catabolic cartilage markers at mRNA and protein level to investigate if physiological mechanical stimulation could have a beneficial effect favoring anabolic ...
, but transient, joint inflammation in the horse. Intra-articular injection of LPS also influences the metabolism of articular cartilage as determined by biomarkers. Parallel profiles of catabolic collagenase ...
knees. Ann Rheum Dis 1997; 56: 299–307. Google Scholar 5 Caterson B, Hughes CE, Roughley P, Mort JS. Anabolic and catabolic markers of proteoglycan metabolism in osteoarthritis. Acta Orthop Scand 1995 ...
and related markers BCAA metabolic pathway is altered because of either joint injury or articular cartilage pathology, whereas arginine catabolism is increased to activate arginine–proline pathway for cartilage ...
) are anabolic factors that contribute to the maintenance of the steady state metabolism of cartilage by stimulating extracellular matrix synthesis (1, 2). IGF-I has been identified as the major stimulatory factor ...
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