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with increased occurrence of bronchiolar epithelial hyperplasia and with metaplastic changes of alveolar epithelium. Squamous carcinoma developed in only a few hamsters and only in those animals receiving radon ...
to induce pulmonary overload, rats developed a more severe and persistent pulmonary inflammatory response than either mice or hamsters . Rats also were unique in the development of progressive ...
, and talc led to the development of lung tumors in rats but not hamsters or mice (Heinrich et al., 1986; Hext, 1994; Lee et al., 1985; Mauderly et al., 1987, 1994; Muhle et al., 1998). The pulmonary response ...
Amiodarone (AM) is an effective antidysrhythmic agent, restricted in use by the development of adverse effects, including potentially fatal AM‐induced pulmonary toxicity (AIPT). Although ...
rats, with the exception that some alveolar macrophages containing small amounts of Cb were widely scattered throughout the alveolar air spaces of the pulmonary parenchyma. However, the number ...
Abstract A method has been developed for detection of altered lung capillary permeability and epithelial cell damage by low levels of nitrogen dioxide. Leakage of tritiated serum, injected ...
macrophages , neutrophils) and target cells (tracheobronchial and alveolar epithelial cells) of the respiratory compartment upon exposure to hypoxia and endotoxin stimulation in vitro. Cells were exposed to 5 ...
, severe pulmonary inflammation with numerous infiltrating macrophages and alveolar proteinosis appeared. After 2 years, dose-dependent high incidences of alveolar /bronchiolar adenomas and carcinomas ...
. Human pulmonary lavage. The method used in the recovery of alveolar macrophages from human subjects has been previously described (Ghio et al., 1998). Briefly, volunteers were recruited through pamphlets ...
and propagate the processes of injury, inflammation and fibrosis. Alveolar macrophages (AMs) play a central role in crystalline silica–induced inflammation and pulmonary pathologies (Hamilton et al., 2008 ...
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