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comparative effectiveness research . It provides a mechanism for synthesizing various sources of information and for updating knowledge in an online fashion as evidence accumulates. CLINICAL Clinical Trials 2012 ...
prespecified designs and the original ALLHAT data. CLINICAL DESIGN Clinical Trials 2013; 10: 807–827 TRIALS Do Bayesian adaptive trials offer advantages for comparative effectiveness research ? Protocol ...
The publication in the Journal of the results of ADAPTABLE (Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-Term Effectiveness )1 comparing two doses of aspirin for the secondary ...
Two‐stage clinical trial designs may be efficient in pharmacogenetics research when there is some but inconclusive evidence of effect modification by a genomic marker. Two‐stage designs allow to stop ...
Abstract: Recent FDA guidance on adaptive clinical trial designs defines bias as "a systematic tendency for the estimate of treatment effect to deviate from its true value", and states ...
]. Although trials related to drug and device development were the initial focus, adaptive designs are applicable to a broad swath of clinical research including many types of clinical trials , comparative ...
comparative effectiveness research View Large Table 1 Randomized trial designs Study design Features Advantages Limitations Individual Each study subject is randomly allocated to his/her treatment Lowest risk ...
was kept constant in both conditions and neutral trials were added to the design in order to investigate the origin of the adaptation and to investigate the specific adaptation effects . Our results showed ...
The International Society for CNS Clinical Trials and Methodology (ISCTM) Adaptive Design Working Group (IADWG) designed a case study simulation exercise to compare the value of traditional versus ...
Clinical research to evaluate the effectiveness of life support systems in acute fatal illness has unique problems of logistics, ethics, and consent. There have been 10 prospective comparative trials ...
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