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THE USE OF HYBRID SOMATIC CELLS AS AN APPROACH TO MITOCHONDRIAL GENETICS IN ANIMALS Igor B. Dawid 1 , Ivan Horak 1 , and Hayden G. Coon 1 1 Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210 Laboratory of Cell Biology, National Cancer Institute, Bethesda, Maryland 20014 We have studied the fate of parental mitochondrial DNA (mtDNA) in hybrid somatic cells derived by Sendai virus-induced fusion of human cells and mouse or rat cells. Many hybrid cell strains were obtained which contained sequences from both human and rodent mtDNA after 40 to 60 population doublings. Some strains were subcloned and cultured further for up to 150 doublings; a large fraction of these strains contained both parental mtDNA sequences at that time. The relation between human and rodent mtDNA sequences was tested in some of the hybrid cell strains. In a high fraction of strains tested the human and rodent mtDNA sequences were linked to each other by what are most likely covalent bonds. This linkage may be described as "recombination" of mtDNA sequences from two different animals. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genetics Genetics Society of America

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