The Drosophila engrailed and invected Genes: Partners in Regulation, Expression and Function

The Drosophila engrailed and invected Genes: Partners in Regulation, Expression and Function Departmt of Biochemistry and Biophysics, University of Calqornia, Sun Francisco, California 94143 Manuscript received September 22, 1995 Accepted for publication December 13, 1995 ABSTRACT We isolated and characterized numerous grailed and inuected alleles. Among the deficicies w e isolated, a mutant lacking invected sequces wasviable and photypically normal, a mutant lacking grailed was an embryo lethal and had slight segmtation defects, andmutant lacking both grailed a and inuectedwas most severely affected. In sev grailed alleles, mutations caused translation to terminate prematurely in the ctral or Gterminal portionthe coding sequce, resulting in embryonic lethality of and segmtation defects. Bothgrailed and invected expression declined prematurely in these mutant embryos. In wild-type embryos, grailed and invected are juxtaposed and are expressed in esstially mgrailed and invected transcription units idtical patterns. A breakpoint mutant that separates the parceled differt aspects of the expression pattern to grailed or inuected. W also found that both e ges cause similar defects wh expressed ectopically and the protein productsof both ges act that e to repress transcription in cultured cells.W propose that the varied photypes of the grailed alleles can be explained b the differtial effects these mutants have on the combination y of grailed and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genetics Genetics Society of America

The Drosophila engrailed and invected Genes: Partners in Regulation, Expression and Function

Loading next page...
 
/lp/genetics-society-of-america/the-drosophila-engrailed-and-invected-genes-partners-in-regulation-KdNyg1lqPS
Publisher
Genetics Society of America
Copyright
Copyright © 1996 by the Genetics Society of America
ISSN
0016-6731
eISSN
1943-2631
Publisher site
See Article on Publisher Site

Abstract

Departmt of Biochemistry and Biophysics, University of Calqornia, Sun Francisco, California 94143 Manuscript received September 22, 1995 Accepted for publication December 13, 1995 ABSTRACT We isolated and characterized numerous grailed and inuected alleles. Among the deficicies w e isolated, a mutant lacking invected sequces wasviable and photypically normal, a mutant lacking grailed was an embryo lethal and had slight segmtation defects, andmutant lacking both grailed a and inuectedwas most severely affected. In sev grailed alleles, mutations caused translation to terminate prematurely in the ctral or Gterminal portionthe coding sequce, resulting in embryonic lethality of and segmtation defects. Bothgrailed and invected expression declined prematurely in these mutant embryos. In wild-type embryos, grailed and invected are juxtaposed and are expressed in esstially mgrailed and invected transcription units idtical patterns. A breakpoint mutant that separates the parceled differt aspects of the expression pattern to grailed or inuected. W also found that both e ges cause similar defects wh expressed ectopically and the protein productsof both ges act that e to repress transcription in cultured cells.W propose that the varied photypes of the grailed alleles can be explained b the differtial effects these mutants have on the combination y of grailed and

Journal

GeneticsGenetics Society of America

Published: Mar 1, 1996

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off