University o f Wisconsin, Madison, Wisconsin Received May 29, 1950 NVESTIGATIONS of the antigenic structure of cattle erythrocytes have been in progress in this laboratory during the past decade. In the first two 1941 STORMONT IRWIN and reports of these studies ( FERGUSON ; FERGUSON, 1942), thirty antigens (called A, B, C, E, G, H, I, J, K, M . . . Z, Aâ, Câ . . . Hâ) were postulated to explain the serological results. Genetically each of these hypothetical substances, as A, or B or C, etc., appeared as a dominant in contrast to its absence, and no two of them behaved as a single pair of alternatives. From these observations, it seemed probable at the time that each of these 30 blood factors represented a discrete antigen controlled by a single gene. Since the possibility was not overlooked that any one of these antigens might be the product of two or more closely linked genes, a minimum of 30 loci was implied. There were, however, several observations that indicated at least one alternative genetic and serological explanation. For example, FERGUSON (1941) had pointed out that the antigen called E had been noted only in combination
Genetics – Genetics Society of America
Published: Mar 1, 1951
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