Sternopleural is a Regulatory Mutation of wingless With Both Dominant and Recessive Effects on Larval Development of Drosophila melanogaster

Sternopleural is a Regulatory Mutation of wingless With Both Dominant and Recessive Effects on... European Molecular Biology Laboratoly 69117 Heidelberg, Germany Manuscript received October 12, 1995 Accepted for publication December 18, 1995 ABSTRACT The Drosophila un.ngless(wg) gene encodes a secreted signaling protein that is required for many separate patterningevents in both embryonic andlarval development. wgfunctionsin the development of the adult structures have been studied using the conditional mutant w$ and also using regulatory mutations of w that reduce larval functions. Herew present evidence thatSternophral (Jib) another g e is regulatory allele of w that affects a subset of larval functions. Sp has both a recessive loss-of-function g component and a gain-of-function component. The loss-of-function component reflects reduction of a wgactivity in the notum and in antenna. The the gain-of-function component apparently leadsectopic to w activity in the dorsal first and second leg disc and thereby generates the dominant phenotype. Jib g Jib and other w alleles show a complex pattern of complementation. W present evidence that these g e genetic propertiesare due to transvection. These results have implications for the genetic definition of a null allele at loci subject to transvection. HE Drosophila wingless (wg) gene is required for many patterning events during embryogenesis and during larval development (reviewed by KLINGENSMITH and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genetics Genetics Society of America

Sternopleural is a Regulatory Mutation of wingless With Both Dominant and Recessive Effects on Larval Development of Drosophila melanogaster

Genetics, Volume 142: 1147 – Apr 1, 1996

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Publisher
Genetics Society of America
Copyright
Copyright © 1996 by the Genetics Society of America
ISSN
0016-6731
eISSN
1943-2631
Publisher site
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Abstract

European Molecular Biology Laboratoly 69117 Heidelberg, Germany Manuscript received October 12, 1995 Accepted for publication December 18, 1995 ABSTRACT The Drosophila un.ngless(wg) gene encodes a secreted signaling protein that is required for many separate patterningevents in both embryonic andlarval development. wgfunctionsin the development of the adult structures have been studied using the conditional mutant w$ and also using regulatory mutations of w that reduce larval functions. Herew present evidence thatSternophral (Jib) another g e is regulatory allele of w that affects a subset of larval functions. Sp has both a recessive loss-of-function g component and a gain-of-function component. The loss-of-function component reflects reduction of a wgactivity in the notum and in antenna. The the gain-of-function component apparently leadsectopic to w activity in the dorsal first and second leg disc and thereby generates the dominant phenotype. Jib g Jib and other w alleles show a complex pattern of complementation. W present evidence that these g e genetic propertiesare due to transvection. These results have implications for the genetic definition of a null allele at loci subject to transvection. HE Drosophila wingless (wg) gene is required for many patterning events during embryogenesis and during larval development (reviewed by KLINGENSMITH and

Journal

GeneticsGenetics Society of America

Published: Apr 1, 1996

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