Genotype-Environment Interaction at Quantitative Trait Loci Affecting Sensory Bristle Number in Drosophila melanogaster

Genotype-Environment Interaction at Quantitative Trait Loci Affecting Sensory Bristle Number in... Marjorie C. Gurganus a , James D. Fry a , Sergey V. Nuzhdin a , Elena G. Pasyukova a,b , Richard F. Lyman a , and Trudy F. C. Mackay a a Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695 b Institute of Molecular Genetics of Russian Academy of Sciences, Moscow 123182, Russia Corresponding author: Trudy F. C. Mackay, Department of Genetics, Box 7614, North Carolina State University, Raleigh, NC 27695., trudy_mackay@ncsu.edu (E-mail). Communicating editor: C. H ALEY The magnitude of segregating variation for bristle number in Drosophila melanogaster exceeds that predicted from models of mutation-selection balance. To evaluate the hypothesis that genotype-environment interaction (GEI) maintains variation for bristle number in nature, we quantified the extent of GEI for abdominal and sternopleural bristles among 98 recombinant inbred lines, derived from two homozygous laboratory strains, in three temperature environments. There was considerable GEI for both bristle traits, which was mainly attributable to changes in rank order of line means. We conducted a genome-wide screen for quantitative trait loci (QTLs) affecting bristle number in each sex and temperature environment, using a dense (3.2-cM) marker map of polymorphic insertion sites of roo transposable elements. Nine sternopleural and 11 abdominal bristle number QTLs were detected. Significant GEI was exhibited by 14 QTLs, but there was heterogeneity among QTLs in their sensitivity to thermal and sexual environments. To further evaluate the hypothesis that GEI maintains variation for bristle number, we require estimates of allelic effects across environments at genetic loci affecting the traits. This level of resolution may be achievable for Drosophila bristle number because candidate loci affecting bristle development often map to the same location as bristle number QTLs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genetics Genetics Society of America

Genotype-Environment Interaction at Quantitative Trait Loci Affecting Sensory Bristle Number in Drosophila melanogaster

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Publisher
Genetics Society of America
Copyright
Copyright © 1998 by the Genetics Society of America
ISSN
0016-6731
eISSN
1943-2631
Publisher site
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Abstract

Marjorie C. Gurganus a , James D. Fry a , Sergey V. Nuzhdin a , Elena G. Pasyukova a,b , Richard F. Lyman a , and Trudy F. C. Mackay a a Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695 b Institute of Molecular Genetics of Russian Academy of Sciences, Moscow 123182, Russia Corresponding author: Trudy F. C. Mackay, Department of Genetics, Box 7614, North Carolina State University, Raleigh, NC 27695., trudy_mackay@ncsu.edu (E-mail). Communicating editor: C. H ALEY The magnitude of segregating variation for bristle number in Drosophila melanogaster exceeds that predicted from models of mutation-selection balance. To evaluate the hypothesis that genotype-environment interaction (GEI) maintains variation for bristle number in nature, we quantified the extent of GEI for abdominal and sternopleural bristles among 98 recombinant inbred lines, derived from two homozygous laboratory strains, in three temperature environments. There was considerable GEI for both bristle traits, which was mainly attributable to changes in rank order of line means. We conducted a genome-wide screen for quantitative trait loci (QTLs) affecting bristle number in each sex and temperature environment, using a dense (3.2-cM) marker map of polymorphic insertion sites of roo transposable elements. Nine sternopleural and 11 abdominal bristle number QTLs were detected. Significant GEI was exhibited by 14 QTLs, but there was heterogeneity among QTLs in their sensitivity to thermal and sexual environments. To further evaluate the hypothesis that GEI maintains variation for bristle number, we require estimates of allelic effects across environments at genetic loci affecting the traits. This level of resolution may be achievable for Drosophila bristle number because candidate loci affecting bristle development often map to the same location as bristle number QTLs.

Journal

GeneticsGenetics Society of America

Published: Aug 1, 1998

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