Manuscript received September 26, 1995 Accepted for publication November 29, 1995 ABSTRACT Fstatistics are functions of probabilities of identity in state. These values Expected values of WRIGHTâS may be quite different under an infinite allele model and under stepwise mutation processes such as those occurring at microsatellite loci. However,a relationship between the probability of identity in state in stepwise mutation models and the distribution of coalescence times can bededuced from the relationship between probabilities of identity by descent and the distribution of coalescence times. The values of F,,and FsTcan be computed using this property. Examination of the conditional probability of identity in state given some coalescence time and of the distribution of coalescence times are also useful for explaining the properties of F,,and FST high mutation rate loci, as shown here in an island model of at population structure. he estimation of WRIGHTâS Fstatistics is standard practice (e.g., WEIR1990) and has multiple uses (e.g., HARTL and CLARK 1989; SLATKIN 1993). Most discussions of their properties have been based on the values of probabilities of identity by descent in the infinite allele model. In a recent paper SLATKIN (1995) has emphasized that such theory may not be appropriate for
Genetics – Genetics Society of America
Published: Apr 1, 1996
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