Anthony D. Long a , Richard F. Lyman b , Alison H. Morgan a , Charles H. Langley a , and Trudy F. C. Mackay b a Center for Population Biology, University of California, Davis, California 95616 b Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695 Corresponding author: Anthony D. Long, Department of Ecology and Evolution, Steinhaus Hall, University of California, Irvine, CA 92697-2525., email@example.com (E-mail) Communicating editor: P. D. K EIGHTLEY A restriction enzyme survey of a 110-kb region including the achaete scute complex ( ASC ) examined 14 polymorphic molecular markers in a sample of 56 naturally occurring chromosomes. Large insertions as a class were associated with a reduction in both sternopleural and abdominal bristle number, supporting deleterious mutation-selection equilibrium models for the maintenance of quantitative genetic variation. Two polymorphic sites were independently associated with variation in bristle number measured in two genetic backgrounds as assessed by a permutation test. A 6-bp deletion near sc α is associated with sternopleural bristle number variation in both sexes and a 3.4-kb insertion between sc ß and sc γ is associated with abdominal bristle number variation in females. Under an additive genetic model, the small deletion polymorphism near sc α accounts for 25% of the total X chromosome genetic variation in sternopleural bristle number, and the 3.4 kb insertion accounts for 22% of the total X chromosome variation in female abdominal bristle number. The observation of common polymorphisms associated with variation in bristle number is more parsimoniously explained by models that incorporate balancing selection or assume variants affecting bristle number are neutral, than mutation-selection equilibrium models.
Genetics – Genetics Society of America
Published: Mar 1, 2000
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