Both Naturally Occurring Insertions of Transposable Elements and Intermediate Frequency Polymorphisms at the achaete-scute Complex Are Associated With Variation in Bristle Number in Drosophila melanogaster

Both Naturally Occurring Insertions of Transposable Elements and Intermediate Frequency... Anthony D. Long a , Richard F. Lyman b , Alison H. Morgan a , Charles H. Langley a , and Trudy F. C. Mackay b a Center for Population Biology, University of California, Davis, California 95616 b Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695 Corresponding author: Anthony D. Long, Department of Ecology and Evolution, Steinhaus Hall, University of California, Irvine, CA 92697-2525., tdlong@uci.edu (E-mail) Communicating editor: P. D. K EIGHTLEY A restriction enzyme survey of a 110-kb region including the achaete scute complex ( ASC ) examined 14 polymorphic molecular markers in a sample of 56 naturally occurring chromosomes. Large insertions as a class were associated with a reduction in both sternopleural and abdominal bristle number, supporting deleterious mutation-selection equilibrium models for the maintenance of quantitative genetic variation. Two polymorphic sites were independently associated with variation in bristle number measured in two genetic backgrounds as assessed by a permutation test. A 6-bp deletion near sc α is associated with sternopleural bristle number variation in both sexes and a 3.4-kb insertion between sc ß and sc γ is associated with abdominal bristle number variation in females. Under an additive genetic model, the small deletion polymorphism near sc α accounts for 25% of the total X chromosome genetic variation in sternopleural bristle number, and the 3.4 kb insertion accounts for 22% of the total X chromosome variation in female abdominal bristle number. The observation of common polymorphisms associated with variation in bristle number is more parsimoniously explained by models that incorporate balancing selection or assume variants affecting bristle number are neutral, than mutation-selection equilibrium models. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genetics Genetics Society of America

Both Naturally Occurring Insertions of Transposable Elements and Intermediate Frequency Polymorphisms at the achaete-scute Complex Are Associated With Variation in Bristle Number in Drosophila melanogaster

Loading next page...
 
/lp/genetics-society-of-america/both-naturally-occurring-insertions-of-transposable-elements-and-jtAZGZ0tcr
Publisher
Genetics Society of America
Copyright
Copyright © 2000 by the Genetics Society of America
ISSN
0016-6731
eISSN
1943-2631
Publisher site
See Article on Publisher Site

Abstract

Anthony D. Long a , Richard F. Lyman b , Alison H. Morgan a , Charles H. Langley a , and Trudy F. C. Mackay b a Center for Population Biology, University of California, Davis, California 95616 b Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695 Corresponding author: Anthony D. Long, Department of Ecology and Evolution, Steinhaus Hall, University of California, Irvine, CA 92697-2525., tdlong@uci.edu (E-mail) Communicating editor: P. D. K EIGHTLEY A restriction enzyme survey of a 110-kb region including the achaete scute complex ( ASC ) examined 14 polymorphic molecular markers in a sample of 56 naturally occurring chromosomes. Large insertions as a class were associated with a reduction in both sternopleural and abdominal bristle number, supporting deleterious mutation-selection equilibrium models for the maintenance of quantitative genetic variation. Two polymorphic sites were independently associated with variation in bristle number measured in two genetic backgrounds as assessed by a permutation test. A 6-bp deletion near sc α is associated with sternopleural bristle number variation in both sexes and a 3.4-kb insertion between sc ß and sc γ is associated with abdominal bristle number variation in females. Under an additive genetic model, the small deletion polymorphism near sc α accounts for 25% of the total X chromosome genetic variation in sternopleural bristle number, and the 3.4 kb insertion accounts for 22% of the total X chromosome variation in female abdominal bristle number. The observation of common polymorphisms associated with variation in bristle number is more parsimoniously explained by models that incorporate balancing selection or assume variants affecting bristle number are neutral, than mutation-selection equilibrium models.

Journal

GeneticsGenetics Society of America

Published: Mar 1, 2000

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off