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INTRODUCTN spontaneous alteratns. These changes may involve large sectns of the chromosomes, or they may be localized about a particular gene. Since these alteratns are subject to variatns, both random and non-random in origin, the methodology by which this variatn is analyzed becomes of major importance to any interpretatn to be attached to such data. Prevus irradiatn experiments have shown that changes in the chromatin can be produced artificially and a t a higher frequency than exists naturally. Differing sources and dosages of radiant energy have been used, and differing types of gene changes have been studied. All those experiments likewise involve, as an integral part of their interpretatn, the random and the non-random variatn mentned above, and its proper analysis. I we have a populatn of Drosophila in which a certain fractn, p, f has mutated from the normal red eye-color to a vermiln eye-color, we say that the probability of observing a mutant fly, on one random observatn of this whole populatn, is p. I the proportn of mutants stays fixed f during the perd of our interest in the populatn, it is well known that the probability of observing exactly r mutants in a sample http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genetics Genetics Society of America

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