Manuscript received June 19, 1994 Accepted for publication ICROSATELLITE loci, loci that vary in the number of repeats of a simple DNA sequence, are becoming commonly used in the analysisof natural populations. Microsatellite loci are often highlypolymorphic and relatively easy to survey and hence offer the hopeof greater understandingof population structure. Thequestion is how to make the best use of allele frequencies at microsatellite loci. This paper, like the accompanying paper by GOLDSTEIN al. (1995),diset cusses how information about the mutation process at microsatellite loci can suggest statistics that are more appropriate for the analysis of microsatellite loci than are existing statistics. In this paper, I will introduce a new statistic analogous to WRIGHT'S (1951)FsT that can be used to estimate effective migration rates or times since population divergence. This statistic is closely relatedthe to distance measures introduced by GOLDSTEIN al. (1995). et FsT and in the limit of small values of p, where is the average coalescence time of two copies of a gene drawn from the same population and Tis the average coalescence time of two copies of a gene drawn from the collection of populations. The result of SLATKIN (1991) for the infinite allele model
Genetics – Genetics Society of America
Published: Jan 1, 1995
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