The study of the possibility of drug dissolution of gallbladder calculi

The study of the possibility of drug dissolution of gallbladder calculi PurposeThe purpose of this paper is to verify the possibility of ultrasonic intensification of drug dissolution of cholesterol calculi of the gallbladder using conventional ultrasound frequency and intensity from 0.1 to 0.5 W/cm2.Design/methodology/approachFor research purposes, the physical model was developed containing pig bile, pig liver, pigskin, fat and muscles, as well as human cholesterol calculus removed by surgery and a drug with ursodeoxycholic acid.FindingsThe studies have shown the possibility of accelerating the drug dissolution of calculi of the gallbladder with ultrasound exposure. The ultrasound intensity of 0.4 W/cm2 is the most preferable to intensify the dissolution of calculus.Originality/valueThe results will be used to advance with development of the device and methodology for ultrasonic intensification of drug dissolution of gallbladder calculi. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Sensor Review Emerald Publishing

The study of the possibility of drug dissolution of gallbladder calculi

Sensor Review, Volume 40 (3): 4 – Jun 15, 2020

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Publisher
Emerald Publishing
Copyright
Copyright © Emerald Group Publishing Limited
ISSN
0260-2288
DOI
10.1108/SR-12-2019-0301
Publisher site
See Article on Publisher Site

Abstract

PurposeThe purpose of this paper is to verify the possibility of ultrasonic intensification of drug dissolution of cholesterol calculi of the gallbladder using conventional ultrasound frequency and intensity from 0.1 to 0.5 W/cm2.Design/methodology/approachFor research purposes, the physical model was developed containing pig bile, pig liver, pigskin, fat and muscles, as well as human cholesterol calculus removed by surgery and a drug with ursodeoxycholic acid.FindingsThe studies have shown the possibility of accelerating the drug dissolution of calculi of the gallbladder with ultrasound exposure. The ultrasound intensity of 0.4 W/cm2 is the most preferable to intensify the dissolution of calculus.Originality/valueThe results will be used to advance with development of the device and methodology for ultrasonic intensification of drug dissolution of gallbladder calculi.

Journal

Sensor ReviewEmerald Publishing

Published: Jun 15, 2020

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