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Synthesizing a nanoparticle distribution in magnetic fluid hyperthermia

Synthesizing a nanoparticle distribution in magnetic fluid hyperthermia Purpose – The purpose of this paper is to present the synthesis of magnetic fluid characteristics, like diameter of nanoparticles (NPs) and their concentration, in order to obtain a prescribed temperature rate. An evolution strategy algorithm is used in the optimization procedure, while three‐dimensional finite‐element (FE) modelling is used for magnetic field and thermal field analysis in transient conditions. Design/methodology/approach – FE analysis has been used in order to compute the magnetic and thermal field in a suitable model of the tumor region. The power density due to NP has been accordingly derived. Findings – The NP distribution, giving a prescribed thermal response, is synthesized. Practical implications – The proposed method can be used to design a therapeutic treatment based on magnetic fluid hyperthermia. Originality/value – The paper belongs to a streamline of innovative studies on computational hyperthermia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png COMPEL: The International Journal for Computation and Mathematics in Electrical and Electronic Engineering Emerald Publishing

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Publisher
Emerald Publishing
Copyright
Copyright © 2011 Emerald Group Publishing Limited. All rights reserved.
ISSN
0332-1649
DOI
10.1108/03321641111152667
Publisher site
See Article on Publisher Site

Abstract

Purpose – The purpose of this paper is to present the synthesis of magnetic fluid characteristics, like diameter of nanoparticles (NPs) and their concentration, in order to obtain a prescribed temperature rate. An evolution strategy algorithm is used in the optimization procedure, while three‐dimensional finite‐element (FE) modelling is used for magnetic field and thermal field analysis in transient conditions. Design/methodology/approach – FE analysis has been used in order to compute the magnetic and thermal field in a suitable model of the tumor region. The power density due to NP has been accordingly derived. Findings – The NP distribution, giving a prescribed thermal response, is synthesized. Practical implications – The proposed method can be used to design a therapeutic treatment based on magnetic fluid hyperthermia. Originality/value – The paper belongs to a streamline of innovative studies on computational hyperthermia.

Journal

COMPEL: The International Journal for Computation and Mathematics in Electrical and Electronic EngineeringEmerald Publishing

Published: Sep 13, 2011

Keywords: Evolutionary computing; Magnetic nanoparticles; FE three‐dimensional transient analysis; Nanotechnology; Magnetohydrodynamics

References