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Prader‐Willi syndrome and hyperphagia: an update

Prader‐Willi syndrome and hyperphagia: an update Purpose – Prader‐Willi syndrome (PWS) is a genetic disorder characterised by excessive appetite and progressive obesity. The causes of hyperphagia are unknown and this has implications on treatment limiting the options available. The purpose of this paper is to systematically synthesise the latest evidence regarding all causes as well as management of hyperphagia in people with PWS. Design/methodology/approach – A computer‐based literature search, citation tracking and related articles search was undertaken. Primary research studies using genetically confirmed Prader‐Willi participants specifically focused on the causes and treatment of overeating was included. Studies were described, critically analysed, presented and discussed in the review. Findings – In total, 18 relevant studies were identified. Nine studies were included in the causes of hyperphagia and focused largely on the roles of secretory hormones, and reward‐related areas of the brain. Nine studies were included in the management of hyperphagia and related to physical exercise and food control, antidiabetic agents and weight loss surgery. Originality/value – The causes and the management of hyperphagia are still to be determined despite promising findings. The small number and heterogeneity of the included studies and participants limits conclusions. There is the need for future research to use larger systematic studies to validate findings so far. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Advances in Mental Health and Intellectual Disabilities Emerald Publishing

Prader‐Willi syndrome and hyperphagia: an update

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Publisher
Emerald Publishing
Copyright
Copyright © 2014 Emerald Group Publishing Limited. All rights reserved.
ISSN
2044-1282
DOI
10.1108/AMHID-07-2013-0048
Publisher site
See Article on Publisher Site

Abstract

Purpose – Prader‐Willi syndrome (PWS) is a genetic disorder characterised by excessive appetite and progressive obesity. The causes of hyperphagia are unknown and this has implications on treatment limiting the options available. The purpose of this paper is to systematically synthesise the latest evidence regarding all causes as well as management of hyperphagia in people with PWS. Design/methodology/approach – A computer‐based literature search, citation tracking and related articles search was undertaken. Primary research studies using genetically confirmed Prader‐Willi participants specifically focused on the causes and treatment of overeating was included. Studies were described, critically analysed, presented and discussed in the review. Findings – In total, 18 relevant studies were identified. Nine studies were included in the causes of hyperphagia and focused largely on the roles of secretory hormones, and reward‐related areas of the brain. Nine studies were included in the management of hyperphagia and related to physical exercise and food control, antidiabetic agents and weight loss surgery. Originality/value – The causes and the management of hyperphagia are still to be determined despite promising findings. The small number and heterogeneity of the included studies and participants limits conclusions. There is the need for future research to use larger systematic studies to validate findings so far.

Journal

Advances in Mental Health and Intellectual DisabilitiesEmerald Publishing

Published: Aug 26, 2014

Keywords: Management; Literature review; Treatment; Causes; Hyperphagia; Prader‐Willi syndrome

References