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Magnetic field generating inductor for cancer hyperthermia research

Magnetic field generating inductor for cancer hyperthermia research Purpose – The purpose of this paper is to continue studies previously reported with the primary focus of optimizing an inductor design. The potential benefits of hyperthermia for cancer therapy, particularly metastatic cancers of the prostate, may be realized by the use of targeted magnetic nanoparticles that are heated by alternating magnetic fields (AMFs). Design/methodology/approach – To further explore the potential of this technology, a high‐throughput cell culture treatment system is needed. The AMF requirements for this research present challenges to the design and manufacture of an induction system because a high flux density field at high frequency must be created in a relatively large volume. Additional challenges are presented by the requirement that the inductor must maintain an operating temperature between 35 and 39°C with continuous duty operation for 1 h or longer. Results of simulation and design of two devices for culture samples and for in vitro tests of multiple samples in uniform field are described. Findings – The inductor design chosen provides a uniform distribution of relatively high magnetic field strength while providing an optimal reduction in the voltage and power requirement. Through development of design and selection of magnetic concentrator, the exposure of the cell cultures to the heat generated by the inductor is minimized. Originality/value – This method of generating uniform high AC magnetic fields in a large volume is beneficial for the study of hyperthermia in cells for a high throughput, necessary for cancer treatment research. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png COMPEL: The International Journal for Computation and Mathematics in Electrical and Electronic Engineering Emerald Publishing

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References (13)

Publisher
Emerald Publishing
Copyright
Copyright © 2011 Emerald Group Publishing Limited. All rights reserved.
ISSN
0332-1649
DOI
10.1108/03321641111152784
Publisher site
See Article on Publisher Site

Abstract

Purpose – The purpose of this paper is to continue studies previously reported with the primary focus of optimizing an inductor design. The potential benefits of hyperthermia for cancer therapy, particularly metastatic cancers of the prostate, may be realized by the use of targeted magnetic nanoparticles that are heated by alternating magnetic fields (AMFs). Design/methodology/approach – To further explore the potential of this technology, a high‐throughput cell culture treatment system is needed. The AMF requirements for this research present challenges to the design and manufacture of an induction system because a high flux density field at high frequency must be created in a relatively large volume. Additional challenges are presented by the requirement that the inductor must maintain an operating temperature between 35 and 39°C with continuous duty operation for 1 h or longer. Results of simulation and design of two devices for culture samples and for in vitro tests of multiple samples in uniform field are described. Findings – The inductor design chosen provides a uniform distribution of relatively high magnetic field strength while providing an optimal reduction in the voltage and power requirement. Through development of design and selection of magnetic concentrator, the exposure of the cell cultures to the heat generated by the inductor is minimized. Originality/value – This method of generating uniform high AC magnetic fields in a large volume is beneficial for the study of hyperthermia in cells for a high throughput, necessary for cancer treatment research.

Journal

COMPEL: The International Journal for Computation and Mathematics in Electrical and Electronic EngineeringEmerald Publishing

Published: Sep 13, 2011

Keywords: Induction; Nanoparticles; Hyperthermia; Magnetic concentrator; Cancer treatment; Magnetic fields; Heat measurement

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