Dietary advice combined with a salicylate, mineral and vitamin supplement (CV247) has some tumour static properties: a phase II study

Dietary advice combined with a salicylate, mineral and vitamin supplement (CV247) has some tumour... Purpose – This pilot study seeks to evaluate whether dietary intervention combined with an oral formulation of sodium salicylate, mineral and vitamin supplements (CV247) altered the rate of progression in patients with malignant disease. Design/methodology/approach – A total of 37 patients were recruited from March 2001 to November 2001 and ran to September 2004. All patients had progressive malignancy at trial entry (def: at least two consecutive increases in tumour markers >10 per cent or radiological progression). Patients, were recommended a diet rich in fresh fruit, vegetables, low in saturated fats, salt and man‐made chemical supplements such as colours and preservatives together with oral CV247 (sodium salicylate, copper gluconate, manganese gluconate and ascorbic acid). Dietary compliance was monitored, from a subgroup, by monthly interviews with the trial dietitian recorded on a linear analogue scale. Quality of life was measured by monthly completion of a Rotterdam symptom check‐list questionnaire and tumour progression measured by radiological assessment and/or tumour markers. Findings – The treatment was well tolerated and compliance with the diet was enthusiastic. Of the two patients with progressive metastatic ovarian carcinoma, one had stabilisation in the disease for five months, the other for 20 months. The 28 heavily pre‐treated patients (including those with metastatic prostate cancer) had no significant clinical response (52 per cent stabilisation for 3.5 months). Of the seven patients with early prostate cancer (no metastasis or hormonal therapy, with pre‐trial increasing PSA), six (86 per cent) had stabilisation of PSA with a mean duration of 17.2 months. Originality/value – This study succeeded in evaluating whether dietary intervention combined with an oral formulation of sodium salicylate, mineral and vitamin supplements (CV247) altered the rate of progression in patients with malignant disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nutrition & Food Science Emerald Publishing

Dietary advice combined with a salicylate, mineral and vitamin supplement (CV247) has some tumour static properties: a phase II study

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Publisher
Emerald Publishing
Copyright
Copyright © 2005 Emerald Group Publishing Limited. All rights reserved.
ISSN
0034-6659
DOI
10.1108/00346650510633846
Publisher site
See Article on Publisher Site

Abstract

Purpose – This pilot study seeks to evaluate whether dietary intervention combined with an oral formulation of sodium salicylate, mineral and vitamin supplements (CV247) altered the rate of progression in patients with malignant disease. Design/methodology/approach – A total of 37 patients were recruited from March 2001 to November 2001 and ran to September 2004. All patients had progressive malignancy at trial entry (def: at least two consecutive increases in tumour markers >10 per cent or radiological progression). Patients, were recommended a diet rich in fresh fruit, vegetables, low in saturated fats, salt and man‐made chemical supplements such as colours and preservatives together with oral CV247 (sodium salicylate, copper gluconate, manganese gluconate and ascorbic acid). Dietary compliance was monitored, from a subgroup, by monthly interviews with the trial dietitian recorded on a linear analogue scale. Quality of life was measured by monthly completion of a Rotterdam symptom check‐list questionnaire and tumour progression measured by radiological assessment and/or tumour markers. Findings – The treatment was well tolerated and compliance with the diet was enthusiastic. Of the two patients with progressive metastatic ovarian carcinoma, one had stabilisation in the disease for five months, the other for 20 months. The 28 heavily pre‐treated patients (including those with metastatic prostate cancer) had no significant clinical response (52 per cent stabilisation for 3.5 months). Of the seven patients with early prostate cancer (no metastasis or hormonal therapy, with pre‐trial increasing PSA), six (86 per cent) had stabilisation of PSA with a mean duration of 17.2 months. Originality/value – This study succeeded in evaluating whether dietary intervention combined with an oral formulation of sodium salicylate, mineral and vitamin supplements (CV247) altered the rate of progression in patients with malignant disease.

Journal

Nutrition & Food ScienceEmerald Publishing

Published: Dec 1, 2005

Keywords: Cancer; Diet; Vitamins; Diseases

References

  • Arachidonic acid metabolism in benign and malignant prostatic tissue in vitro : effects of fatty acids and cyclooxygenase inhibitors
    Chaudry, A.A.; Wahle, K.W.; McClinton, S.; Moffatt, L.E.
  • Over‐expression of cyclooxygenase‐2 in human prostate adenocarcinoma
    Gupta, S.; Srivastava, M.; Ahmed, N.; Al, E.
  • Cytoplasmic induction and over‐expression of cyclooxygenase‐2 in human prostate cancer: implications for prevention and treatment
    Madaan, S.; Abel, P.D.; Chaudhary, K.S.; Hewitt, R.; Stott, M.A.; Stamp, G.W.; Lalani, E.N.
  • Evidence for breaking of the active site dimetal cluster in Cu,Co superoxide dismutase upon copper reduction: a polarized absorption spectra study
    Merli, A.; Rossi, G.; Djinovic‐Carugo, K.; Bolognesi, M.; Desideri, A.; Rotilio, G.
  • Beta‐carotene and animal fats and their relationship to prostate cancer risk: a case‐control study
    Mettlin, C.

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