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Antioxidant Vitamins, Free Radicals and Coronary Heart Disease

Antioxidant Vitamins, Free Radicals and Coronary Heart Disease In 1988 over half of the deaths in the world were due to heartdisease. The recognised risk factors for coronary heart disease aresmoking, plasma cholesterol levels and hypertension. These factors,however, account only for some 5060 per cent of the variance inincidence of the disease between countries so other factors mustcontribute. Recent biochemical evidence suggests that in conditions ofoxidant stress a relative deficiency in antioxidants, in conjunctionwith a relatively high concentration of oxidisable substrates such ascholesterol, may play an important role in the development of atheroma.The efficiency of the human antioxidant defence system depends in parton an adequate intake of foods containing antioxidants such as vitaminsC and E. Until intervention trials with these antioxidants show positiveeffects in reducing coronary heart disease, advising the generalpopulation to increase intake of Vitamin C and E is contentious. On theother hand increasing consumption of fruit and vegetables is unlikely todo any harm, and may do us some good. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Food Journal Emerald Publishing

Antioxidant Vitamins, Free Radicals and Coronary Heart Disease

British Food Journal , Volume 92 (8): 5 – Aug 1, 1990

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Publisher
Emerald Publishing
Copyright
Copyright © Emerald Group Publishing Limited
ISSN
0007-070X
DOI
10.1108/EUM0000000002328
Publisher site
See Article on Publisher Site

Abstract

In 1988 over half of the deaths in the world were due to heartdisease. The recognised risk factors for coronary heart disease aresmoking, plasma cholesterol levels and hypertension. These factors,however, account only for some 5060 per cent of the variance inincidence of the disease between countries so other factors mustcontribute. Recent biochemical evidence suggests that in conditions ofoxidant stress a relative deficiency in antioxidants, in conjunctionwith a relatively high concentration of oxidisable substrates such ascholesterol, may play an important role in the development of atheroma.The efficiency of the human antioxidant defence system depends in parton an adequate intake of foods containing antioxidants such as vitaminsC and E. Until intervention trials with these antioxidants show positiveeffects in reducing coronary heart disease, advising the generalpopulation to increase intake of Vitamin C and E is contentious. On theother hand increasing consumption of fruit and vegetables is unlikely todo any harm, and may do us some good.

Journal

British Food JournalEmerald Publishing

Published: Aug 1, 1990

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