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thus creating a source of instability (Taxis and Knop, 2006). Multiple integration of single genes can be achieved using integration sites that occur in multiple copies in the yeast genome . A common ...
in experimental settings. Thus, information about the mutational signature of redox stress–induced oxidative damage in ssDNA can be useful for defining the sources of mutation burden in cancer genomes . Identifying ...
Abstract Approximately 13% of the human genome can fold into non-canonical (non-B) DNA structures (e.g. G-quadruplexes, Z- DNA , etc.), which have been implicated in vital cellular processes. Non-B DNA ...
replicates) using MasterPure Yeast DNA Purification kit (Epicentre) ∼100 generations after sporulation. Genomic DNAs were digested with XhoI restriction enzyme (NEB), separated by 1% (w/v) agarose gel ...
predisposition in early life and male infertility [1,2]. Early cytogenetic experiments revealed clues about the underlying mechanism with patient chromosomes exhibiting hyper-recombination and genome instability ...
double strand breaks (DSBs) can arise during normal cellular processes such as replication stress and replication fork collapse, as well as programmed genomic rearrangements including yeast mating-type ...
Abstract Transposable elements amplify in genomes as selfish DNA elements and challenge host fitness because their intrinsic integration steps during mobilization can compromise genome integrity ...
Abstract Genomic instability contributes to a variety of potentially damaging conditions, including DNA -based rearrangements. Breakage in the form of double strand breaks (DSBs) increases ...
of inter-chromosomal recombination that can cause genomic instability (44,45). The high GC-content of rDNA can also increase G-quadruplex formation, contributing to replication stress and potentially double ...
throughout the human genome over the lifetime of the individual. Studies with transgenic mice have demonstrated that genome instability increases with age and in agreement with tissue-specific proliferation ...
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