XRCC1 phosphorylation affects aprataxin recruitment and DNA deadenylation activity

XRCC1 phosphorylation affects aprataxin recruitment and DNA deadenylation activity •Phosphorylation of XRCC1 critical for its interaction with the FHA domain of APTX.•Expression of XRCC1 phosphorylation mutant designed to eliminate APTX binding.•Phosphorylated XRCC1 required for APTX-GFP recruitment at micro-irradiation damage.•Phosphorylation of XRCC1 greatly enhanced APTX-mediated DNA deadenylation activity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png DNA Repair Elsevier

XRCC1 phosphorylation affects aprataxin recruitment and DNA deadenylation activity

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
1568-7864
D.O.I.
10.1016/j.dnarep.2018.02.004
Publisher site
See Article on Publisher Site

Abstract

•Phosphorylation of XRCC1 critical for its interaction with the FHA domain of APTX.•Expression of XRCC1 phosphorylation mutant designed to eliminate APTX binding.•Phosphorylated XRCC1 required for APTX-GFP recruitment at micro-irradiation damage.•Phosphorylation of XRCC1 greatly enhanced APTX-mediated DNA deadenylation activity.

Journal

DNA RepairElsevier

Published: Apr 1, 2018

References

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