Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!
. This indicates that while MDC1 is not necessary for the initial recruitment of aprataxin to sites of DNA DSB, its absence affects the retention of aprataxin to these sites. On the other hand, loss of XRCC1 ...
ligase IIIα and is constitutively phosphorylated by casein kinase II. In this study we demonstrate that DNA ligase IIIα, unlike XRCC1 , is phosphorylated in a cell cycle-dependent manner. Specifically, DNA ...
Abstract Ataxia with oculomotor apraxia type 1 (AOA1) is an early onset progressive spinocerebellar ataxia caused by mutation in aprataxin (APTX). APTX removes 5′-AMP groups from DNA , a product ...
, an interaction that is critical for recruitment to replication foci (14,40,43). In addition, the DNA ligase I N-terminal region is involved in a phosphorylation -regulated interaction with replication factor C (44 ...
proteins TDP1, aprataxin , and XRCC1 are mutated, respectively (7–10). Arguably one of the most common sources of neurological disease associated with defects in DNA strand break repair are mutations ...
, ATR and DNA -PK (Rogakou et al., 1998; Blackford and Jackson, 2017). Phosphorylated H2AX recruits the mediator of DNA damage checkpoint 1 (MDC1) (Hartlerode and Scully, 2009), inducing the recruitment ...
molecular recognition of the XRCC1 and XRCC4 DNA -damage scaffolds by aprataxin -family FHA domains . DNA Repair (Amst) 2015 ; 35 : 116 – 25 . Google Scholar Crossref Search ADS PubMed WorldCat 27. Leber R ...
of ataxia telangiectasia (mutated) (ATM) kinase and checkpoint kinase 2 (CHK2), which respond to DNA damage through the phosphorylation and hence activation of TAp63. Activation of TAp63 leads ...
protein 1 ( XRCC1 ) to the sites of Top I-induced DNA damage and leads to the stabilization of TDP1 in response to TopIcc-induced DNA damage (Figure 7A) (59). In human cells, TDP1 is phosphorylated at serine ...
, Gueven and Grattan-Smith 2008), little is known about whether and how simple lesions, such as SSBs, alert the DNA damage checkpoints, but it was reported in human cells that XRCC1 is phosphorylated ...
Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!