Wingless Signaling Leads to an Asymmetric Response to Decapentaplegic-Dependent Signaling during Sense Organ Patterning on the Notum of Drosophila melanogaster

Wingless Signaling Leads to an Asymmetric Response to Decapentaplegic-Dependent Signaling during... Wnt and Decapentaplegic cell signaling pathways act synergistically in their contribution to macrochaete (sense organ) patterning on the notum of Drosophila melanogaster. The Wingless-signaling pathway was ectopically activated by removing Shaggy activity (the homologue of vertebrate glycogen synthase kinase 3) in mosaics. Proneural activity is asymmetric within the Shaggy-deficient clone of cells and shows a fixed “polarity” with respect to body axis, independent of the precise location of the clone. This asymmetric response indicates the existence in the epithelium of a second signal, which we suggest is Decapentaplegic. Ectopic expression of Decapentaplegic induces extra macrochaetes only in cells which also receive the Wingless signal. Activation of Hedgehog signaling generates a long-range signal which can promote macrochaete formation in the Wingless activity domain. This signal depends upon decapentaplegic function. Autonomous activation of the Wingless signal response in cells causes them to attenuate or sequester this signal. Our results suggest a novel patterning mechanism which determines sense organ positioning in Drosophila . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Developmental Biology Elsevier

Wingless Signaling Leads to an Asymmetric Response to Decapentaplegic-Dependent Signaling during Sense Organ Patterning on the Notum of Drosophila melanogaster

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Publisher
Elsevier
Copyright
Copyright © 1999 Academic Press
ISSN
0012-1606
eISSN
1095-564X
DOI
10.1006/dbio.1998.9149
Publisher site
See Article on Publisher Site

Abstract

Wnt and Decapentaplegic cell signaling pathways act synergistically in their contribution to macrochaete (sense organ) patterning on the notum of Drosophila melanogaster. The Wingless-signaling pathway was ectopically activated by removing Shaggy activity (the homologue of vertebrate glycogen synthase kinase 3) in mosaics. Proneural activity is asymmetric within the Shaggy-deficient clone of cells and shows a fixed “polarity” with respect to body axis, independent of the precise location of the clone. This asymmetric response indicates the existence in the epithelium of a second signal, which we suggest is Decapentaplegic. Ectopic expression of Decapentaplegic induces extra macrochaetes only in cells which also receive the Wingless signal. Activation of Hedgehog signaling generates a long-range signal which can promote macrochaete formation in the Wingless activity domain. This signal depends upon decapentaplegic function. Autonomous activation of the Wingless signal response in cells causes them to attenuate or sequester this signal. Our results suggest a novel patterning mechanism which determines sense organ positioning in Drosophila .

Journal

Developmental BiologyElsevier

Published: Mar 1, 1999

References

  • Genetic relationships between the mutations spade Sternopleural wingless Drosophila
    Buratovich, M.A.; Phillips, R.G.; Whittle, J.R.S.
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  • Decapentaplegic overexpression affects Drosophila wingless
    Morimura, S.; Maves, L.; Chen, Y.J.; Hoffmann, F.M.
  • A stable genomic source of P-element transposase in Drosophila melanogaster
    Robertson, H.M.; Preston, C.R.; Phillis, R.W.; Johnson-Schlitz, D.M.; Benz, W.K.; Engels, W.R.
  • Notch in vertebrates
    Robey, E.
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    Simin, K.; Bates, E.A.; Horner, M.A.; Letsou, A.

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