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R. Govindan, E. Siegel, S. Mckelvey, P. Murphy, C. Lowery, H. Eswaran (2015)
Tracking the Changes in Synchrony of the Electrophysiological Activity as the Uterus Approaches Labor Using Magnetomyographic TechniqueReproductive Sciences, 22
R. Young, L. Smith, M. Mclaren (1993)
T-type and L-type calcium currents in freshly dispersed human uterine smooth muscle cells.American journal of obstetrics and gynecology, 169 4
Conor McCloskey, C. Rada, E. Bailey, S. McCavera, H. Berg, Jolene Atia, D. Rand, A. Shmygol, Yi‐Wah Chan, S. Quenby, J. Brosens, M. Vatish, Jie Zhang, J. Denton, M. Taggart, C. Kettleborough, David Tickle, J. Jerman, P. Wright, T. Dale, S. Kanumilli, D. Trezise, S. Thornton, P. Brown, R. Catalano, N. Lin, S. England, A. Blanks (2014)
The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancyEMBO Molecular Medicine, 6
R. Garfield, S. Sims, E. Daniel (1977)
Gap junctions: their presence and necessity in myometrium during parturition.Science, 198 4320
Michael Lai, Yuejin Wu, Zhan Gao, M. Anderson, J. Dalziel, A. Meredith (2014)
BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo.American journal of physiology. Heart and circulatory physiology, 307 9
M. Melamed, E. Castaño, A. Notides, S. Sasson (1997)
Molecular and kinetic basis for the mixed agonist/antagonist activity of estriol.Molecular endocrinology, 11 12
M. Mclean, A. Bisits, J. Davies, R. Woods, P. Lowry, Roger Smith (1995)
A placental clock controlling the length of human pregnancyNature Medicine, 1
A. Csapo (1970)
The diagnostic significance of the intrauterine pressure. II. Clinical considerations and trials.Obstetrical & gynecological survey, 25 6
Nora Renthal, Chien-Cheng Chen, Koriand'r Williams, R. Gerard, J. Prange‐Kiel, C. Mendelson (2010)
miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and laborProceedings of the National Academy of Sciences, 107
N. Sakai, T. Tabb, R. Garfield (1992)
Studies of connexin 43 and cell-to-cell coupling in cultured human uterine smooth muscle.American journal of obstetrics and gynecology, 167 5
G. Caglioti (1992)
The Dynamics of Ambiguity
E. Tyson, D. MacIntyre, Roger Smith, E. Chan, M. Read (2008)
Evidence that a protein kinase A substrate, small heat-shock protein 20, modulates myometrial relaxation in human pregnancy.Endocrinology, 149 12
H. Parkington, H. Coleman (2001)
Excitability in uterine smooth muscle.Frontiers of hormone research, 27
R. Young, P. Barendse (2014)
Linking Myometrial Physiology to Intrauterine Pressure; How Tissue-Level Contractions Create Uterine Contractions of LaborPLoS Computational Biology, 10
A. Bisits, Roger Smith, S. Mesiano, G. Yeo, K. Kwek, D. MacIntyre, E. Chan (2005)
Inflammatory Aetiology of Human Myometrial Activation Tested Using Directed GraphsPLoS Computational Biology, 1
R. Garfield, W. Maner, H. Maul, G. Saade (2005)
Use of uterine EMG and cervical LIF in monitoring pregnant patientsBJOG: An International Journal of Obstetrics & Gynaecology, 112
R. Young, Peisheng Zhang (2005)
Inhibition of in vitro contractions of human myometrium by mibefradil, a T-type calcium channel blocker: support for a model using excitation-contraction coupling, and autocrine and paracrine signaling mechanisms.Journal of the Society for Gynecologic Investigation, 12 4
N. Benkusky, V. Korovkina, Adam Brainard, S. England (2002)
Myometrial maxi‐K channel β1 subunit modulation during pregnancy and after 17β‐estradiol stimulationFEBS Letters, 524
E. Tyson, Roger Smith, M. Read (2009)
Evidence that corticotropin-releasing hormone modulates myometrial contractility during human pregnancy.Endocrinology, 150 12
N. Carnot
Reflections on the Motive Power of Fire
H. Parkington, J. Stevenson, M. Tonta, J. Paul, Trent Butler, K. Maiti, E. Chan, P. Sheehan, S. Brennecke, H. Coleman, Roger Smith (2014)
Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese womenNature Communications, 5
Nora Renthal, Koriand'r Williams, C. Mendelson (2013)
MicroRNAs—mediators of myometrial contractility during pregnancy and labourNature Reviews Endocrinology, 9
A. Csapo (1956)
Progesterone “block.”, 98
I. Prigogine, I. Stengers (1997)
The end of certainty : time, chaos, and the new laws of nature
M. Slattery, C. Brennan, M. O'Leary, J. Morrison (2001)
Human chorionic gonadotrophin inhibition of pregnant human myometrial contractilityBJOG: An International Journal of Obstetrics & Gynaecology, 108
J. Copeland, A. Moiseff (2004)
Flash Precision at the Start of Synchrony in Photuris frontalis1, 44
G. Europe-Finner, S. Phaneuf, A Tolkovsky, S. Watson, A. Bernal (1994)
Down-regulation of G alpha s in human myometrium in term and preterm labor: a mechanism for parturition.The Journal of clinical endocrinology and metabolism, 79 6
Roger Smith, S. Mesiano, E. Chan, S. Brown, R. Jaffe (1998)
Corticotropin-releasing hormone directly and preferentially stimulates dehydroepiandrosterone sulfate secretion by human fetal adrenal cortical cells.The Journal of clinical endocrinology and metabolism, 83 8
D. MacIntyre, E. Tyson, M. Read, Roger Smith, G. Yeo, K. Kwek, E. Chan (2008)
Contraction in human myometrium is associated with changes in small heat shock proteins.Endocrinology, 149 1
Malcolm. MacDougall, G. Europe-Finner, Stephen Robson (2003)
Human myometrial quiescence and activation during gestation and parturition involve dramatic changes in expression and activity of particulate type II (RII alpha) protein kinase A holoenzyme.The Journal of clinical endocrinology and metabolism, 88 5
R. Word, D. Tang, K. Kamm (1994)
Activation properties of myosin light chain kinase during contraction/relaxation cycles of tonic and phasic smooth muscles.The Journal of biological chemistry, 269 34
(2005)
Synchronization analysis of the uterine magnetic activity during contractions
Koriand'r Williams, Nora Renthal, R. Gerard, C. Mendelson (2012)
The microRNA (miR)-199a/214 cluster mediates opposing effects of progesterone and estrogen on uterine contractility during pregnancy and labor.Molecular endocrinology, 26 11
E. Caglioti, V. Loreto (1996)
Dynamical properties and predictability of a class of self-organized critical models.Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics, 53 3
W. Tong, R. Tribe, Roger Smith, M. Taggart (2014)
Computational Modeling Reveals Key Contributions of KCNQ and hERG Currents to the Malleability of Uterine Action Potentials Underpinning LaborPLoS ONE, 9
Roger Smith, Julia Smith, Xiaobin Shen, Patricia Engel, M. Bowman, S. McGrath, A. Bisits, P. McElduff, W. Giles, David Smith (2009)
Patterns of plasma corticotropin-releasing hormone, progesterone, estradiol, and estriol change and the onset of human labor.The Journal of clinical endocrinology and metabolism, 94 6
R. Fanchin, J. Ayoubi, C. Righini, Francıois Olivennes, L. Schonauer, R. Frydman (2001)
Uterine contractility decreases at the time of blastocyst transfers.Human reproduction, 16 6
A. Csapo, E. Knobil, H. Molen, W. Wiest (1971)
Peripheral plasma progesterone levels during human pregnancy and labor.American journal of obstetrics and gynecology, 110 5
The heart and the laboring uterus use different mechanisms to coordinate contractions. Click Supplemental Materials under the article title in the online Table of Contents</P>This is a discussion of synchrony and coupled oscillatory behavior in the context of the physiology of the laboring uterus and the heart.</P>One of the great marvels of life is the degree of order that is created as life captures energy and transforms it into physiological structure and function against the forces of entropy (second law of thermodynamics 1 ). Life in many ways is a battle against entropy that is inevitably lost for each individual. For human beings, this battle occurs continuously to preserve the function of each tissue. The battle is most heated in the organs that require the most energy: the brain, heart, and laboring uterus. Each uses energy to produce highly organized behavior.</P>During pregnancy the mother’s body diverts a large amount of blood flow to the uterus. This increased blood flow carries energy that is used to create order in the developing fetus. Blood flow and energy are also required to create the regular powerful contractions required for human labor. Intriguingly, the human uterus displays a low level of order
American Journal of Obstetrics and Gynecology – Wolters Kluwer Health
Published: Aug 1, 2015
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