Whole almonds and almond fractions reduce aberrant crypt foci in a rat model of colon carcinogenesis

Whole almonds and almond fractions reduce aberrant crypt foci in a rat model of colon carcinogenesis Almonds and other nuts appear to confer health benefits despite their high fat content. To assess the effect of almonds on colon cancer, whole almond-, almond meal- or almond oil-containing diet effects on aberrant crypt foci (ACF) in azoxymethane-treated F344 male rats were investigated. Six-week-old male F344 rats were fed the various almond and control diets and given subcutaneous injections of azoxymethane (15 mg/kg body weight) twice 1 week apart. After 26 weeks animals were injected with bromodeoxyuridine 1 h prior to sacrifice, after which colons were evaluated for ACF and cell turnover (labeling index, LI). Whole almond ACF and LI were both significantly lower than wheat bran and cellulose diet groups (−30 and −40%, respectively), while almond meal and almond oil ACF and almond meal LI declines were only significant vs. cellulose ( P <0.05). These results suggest that almond consumption may reduce colon cancer risk and does so via at least one almond lipid-associated component. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Letters Elsevier

Whole almonds and almond fractions reduce aberrant crypt foci in a rat model of colon carcinogenesis

Cancer Letters, Volume 165 (1) – Apr 10, 2001

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Science Ireland Ltd
ISSN
0304-3835
D.O.I.
10.1016/S0304-3835(01)00425-6
Publisher site
See Article on Publisher Site

Abstract

Almonds and other nuts appear to confer health benefits despite their high fat content. To assess the effect of almonds on colon cancer, whole almond-, almond meal- or almond oil-containing diet effects on aberrant crypt foci (ACF) in azoxymethane-treated F344 male rats were investigated. Six-week-old male F344 rats were fed the various almond and control diets and given subcutaneous injections of azoxymethane (15 mg/kg body weight) twice 1 week apart. After 26 weeks animals were injected with bromodeoxyuridine 1 h prior to sacrifice, after which colons were evaluated for ACF and cell turnover (labeling index, LI). Whole almond ACF and LI were both significantly lower than wheat bran and cellulose diet groups (−30 and −40%, respectively), while almond meal and almond oil ACF and almond meal LI declines were only significant vs. cellulose ( P <0.05). These results suggest that almond consumption may reduce colon cancer risk and does so via at least one almond lipid-associated component.

Journal

Cancer LettersElsevier

Published: Apr 10, 2001

References

  • Cancer statistics 1998
    Landis, S.H.; Murray, T.; Bolden, S.; Wingo, P.A.
  • Nut consumption, lipids, and risk of a coronary event
    Fraser, G.E.
  • Further investigation of the effect of cholic acid on the induction, growth characteristics and stability of aberrant crypt foci in rat colon
    Bird, R.P.

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