White matter ischaemia

White matter ischaemia Brain and spinal cord white matter are vulnerable to the effects of ischaemia. Reduction of the energy supply leads to a cascade of events including depolarization, influx of Na + and the subsequent reverse operation of the membrane protein the Na + /Ca 2+ exchanger which ultimately terminates in intracellular Ca 2+ overload and irreversible axonal injury. Various points along the white matter damage cascade could be specifically targeted as a potential means of inhibiting the development of axonal irreversible injury. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Reviews Elsevier

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Publisher
Elsevier
Copyright
Copyright © 1999 Elsevier Ltd
ISSN
0165-0173
D.O.I.
10.1016/S0165-0173(99)00025-9
Publisher site
See Article on Publisher Site

Abstract

Brain and spinal cord white matter are vulnerable to the effects of ischaemia. Reduction of the energy supply leads to a cascade of events including depolarization, influx of Na + and the subsequent reverse operation of the membrane protein the Na + /Ca 2+ exchanger which ultimately terminates in intracellular Ca 2+ overload and irreversible axonal injury. Various points along the white matter damage cascade could be specifically targeted as a potential means of inhibiting the development of axonal irreversible injury.

Journal

Brain Research ReviewsElsevier

Published: Dec 1, 1999

References

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    Binder, L.I; Frankfurter, A; Rebhun, L.I
  • The perinodal astrocyte
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    Chiu, S.Y; Kriegler, S
  • Tau protein is altered by focal cerebral ischaemia in the rat: immunohistochemical and immunoblotting study
    Dewar, D; Dawson, D
  • Modulation of anoxic injury in CNS white matter by adenosine and interaction between adenosine and GABA
    Fern, R; Waxman, S.G; Ransom, B.R
  • Voltage-gated calcium channels in CNS white matter: role in anoxic injury
    Fern, R; Ransom, B.R; Waxman, S.G
  • Oligodendroglial precursor cell susceptibility to hypoxia is related to poor ability to cope with reactive oxygen species
    Husain, J; Juurlink, B.H
  • Reoxygenation of anoxic peripheral nerve myelinated axons promotes re-establishment of normal elemental composition
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  • The neuronal cytoskeleton and its role in axonal dendritic plasticity
    Ludin, B; Matus, A
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    Ransom, B.R; Fern, R
  • Tertiary and quaternary local anesthetics protect CNS white matter from anoxic injury at concentrations that do not block excitability
    Stys, P.K; Ransom, B.R; Waxman, S.G
  • Cultured rat astrocytes possess Na + –Ca 2+ exchanger
    Takuma, K; Matsuda, T; Hashimoto, H; Asano, S; Baba, A
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    Waxman, S.G; Ritchie, J.M
  • Amyloid precursor protein accumulates in white matter at the margin of a focal ischaemic lesion
    Yam, P.S; Takasago, T; Dewar, D; Graham, D.I; McCulloch, J

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