1 Introduction</h5> The results of several studies suggest that a large percentage of the world's horse population is overweight or obese. It is estimated that between 40% and 50% of horses have a body condition score (BCS) ≥6/9, with 18.7% to 20% meeting obesity standards (BCS, >7/9) [1–5] . Overweight horses may have an increased risk of laminitis, insulin (INS) resistance, and equine metabolic syndrome [6–12] . Obesity has been hypothesized to contribute to INS resistance through the disruption of INS signaling pathways by adipokines and proinflammatory cytokines [13–17] . Several studies have linked the INS-resistant phenotype to a predisposition for laminitis [18,19] . Furthermore, it has been reported that the risk for laminitis is the highest when horses are grazing lush pasture, particularly in the spring and late fall [20,21] . The large number of obese horses and the risks associated with obesity have necessitated research investigating methods for weight loss in horses.</P>A reduction of body weight (BW), body condition, and basal INS concentration has been achieved by restricting calorie and dry matter intake (DMI) in controlled conditions over a duration of 6 to 18 weeks of study. Feeding 1.0% to 1.25% BW in DMI and 67%
Journal of Equine Veterinary Science – Elsevier
Published: Apr 1, 2016
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