Bioorganic & Medicinal Chemistry Letters 28 (2018) 1097–1100 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Water-soluble polyol-methanofullerenes as mitochondria-targeted antioxidants: Mechanism of action a,⇑ a b b Natalia V. Kalacheva , Gulzada R. Tarasova , Guzel M. Fazleeva , Valentina P. Gubskaya , a a a Dilara R. Gumerova , Albert A. Rizvanov , Georgi V. Cherepnev Kazan Federal University, Kremlevskaya Str. 18, 420008 Kazan, Russian Federation A.E. Arbuzov Institute of Organic and Physical Chemistry of Kazan Scientiﬁc Centre of RAS, Arbuzov Str. 8, 420088 Kazan, Russian Federation article i nfo abstract Article history: The mechanism of an antioxidant action of water-soluble polyol – methanofullerenes C [C H O (OH) ] 60 9 10 4 4 6 Received 12 October 2017 and C [C H O (OH) ] as the mild uncouplers of an oxidative phosphorylation and respiration is 60 13 18 4 4 6 Revised 10 January 2018 postulated. According to this mechanism, hydroxyl group of methanofullerenols can be protonated under Accepted 7 February 2018 excess of protons in the intermembrane space of hyperpolarized mitochondria. Protonation of fullerene Available online 8 February 2018 derivatives is conﬁrmed by the decrease in their negative
Bioorganic & Medicinal Chemistry Letters – Elsevier
Published: Apr 1, 2018
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