Water-soluble polyol-methanofullerenes as mitochondria-targeted antioxidants: Mechanism of action

Water-soluble polyol-methanofullerenes as mitochondria-targeted antioxidants: Mechanism of action Bioorganic & Medicinal Chemistry Letters 28 (2018) 1097–1100 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Water-soluble polyol-methanofullerenes as mitochondria-targeted antioxidants: Mechanism of action a,⇑ a b b Natalia V. Kalacheva , Gulzada R. Tarasova , Guzel M. Fazleeva , Valentina P. Gubskaya , a a a Dilara R. Gumerova , Albert A. Rizvanov , Georgi V. Cherepnev Kazan Federal University, Kremlevskaya Str. 18, 420008 Kazan, Russian Federation A.E. Arbuzov Institute of Organic and Physical Chemistry of Kazan Scientific Centre of RAS, Arbuzov Str. 8, 420088 Kazan, Russian Federation article i nfo abstract Article history: The mechanism of an antioxidant action of water-soluble polyol – methanofullerenes C [C H O (OH) ] 60 9 10 4 4 6 Received 12 October 2017 and C [C H O (OH) ] as the mild uncouplers of an oxidative phosphorylation and respiration is 60 13 18 4 4 6 Revised 10 January 2018 postulated. According to this mechanism, hydroxyl group of methanofullerenols can be protonated under Accepted 7 February 2018 excess of protons in the intermembrane space of hyperpolarized mitochondria. Protonation of fullerene Available online 8 February 2018 derivatives is confirmed by the decrease in their negative http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bioorganic & Medicinal Chemistry Letters Elsevier

Water-soluble polyol-methanofullerenes as mitochondria-targeted antioxidants: Mechanism of action

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0960-894x
D.O.I.
10.1016/j.bmcl.2018.02.009
Publisher site
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Abstract

Bioorganic & Medicinal Chemistry Letters 28 (2018) 1097–1100 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Water-soluble polyol-methanofullerenes as mitochondria-targeted antioxidants: Mechanism of action a,⇑ a b b Natalia V. Kalacheva , Gulzada R. Tarasova , Guzel M. Fazleeva , Valentina P. Gubskaya , a a a Dilara R. Gumerova , Albert A. Rizvanov , Georgi V. Cherepnev Kazan Federal University, Kremlevskaya Str. 18, 420008 Kazan, Russian Federation A.E. Arbuzov Institute of Organic and Physical Chemistry of Kazan Scientific Centre of RAS, Arbuzov Str. 8, 420088 Kazan, Russian Federation article i nfo abstract Article history: The mechanism of an antioxidant action of water-soluble polyol – methanofullerenes C [C H O (OH) ] 60 9 10 4 4 6 Received 12 October 2017 and C [C H O (OH) ] as the mild uncouplers of an oxidative phosphorylation and respiration is 60 13 18 4 4 6 Revised 10 January 2018 postulated. According to this mechanism, hydroxyl group of methanofullerenols can be protonated under Accepted 7 February 2018 excess of protons in the intermembrane space of hyperpolarized mitochondria. Protonation of fullerene Available online 8 February 2018 derivatives is confirmed by the decrease in their negative

Journal

Bioorganic & Medicinal Chemistry LettersElsevier

Published: Apr 1, 2018

References

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