Volitional consumption of ethanol by fawn-hooded rats: Effects of alternative solutions and drug treatments

Volitional consumption of ethanol by fawn-hooded rats: Effects of alternative solutions and drug... Behavioral and neurochemical measures of brain 5-hydroxytryptamine (5-HT) function in the Fawn-Hooded rat are abnormal relative to outbred strains of rats. Fawn-Hooded rats freely drink large amounts of 10% ethanol in the presence of water and have been proposed to be an animal model for studies related to alcoholism. In this study, Fawn-Hooded rats were given solutions of ethanol increasing in concentration from 3% to 30% (w/v in tap water) over 10 days with tap water in a second drinking tube and a third tube left empty. The solutions of ethanol that produced maximal drinking with a preference (ml ethanol/ml total fluid) near 50% ranged from 5% to 13%, which became: the fixed individual concentrations for each rat. After a 5-day baseline period the rats were offered a solution in the third drinking tube of either 0.5% aspartame or chocolate Ultra SlimFast (diluted with water 2: 1). The chocolate drink, but not aspartame, significantly reduced the consumption of alcohol by 73%. For the drug experiments, the rats were given successive 4-day periods of: baseline drinking; drug or saline injections b.i.d.; and a posttreatment period. Neither ipsapirone, a 5-HT 1a partial agonist, nor naltrexone injected inhibited the intakes of ethanol solutions. Treatment with 2.5 mg/kg of amperozide, a 5-HT 2 antagonist, decreased the consumption of ethanol by 38%, but also caused a decrease in consumption of food. These results show a pattern of drinking of increasing concentrations of ethanol different than other strains of rats. Because ethanol intakes of the Fawn-Hooded rat decline precipitously when offered palatable chocolate drink and fail to respond to drugs known to decrease human ethanol intake, this strain may not be a valid model for testing the effects of centrally acting drugs on the consumption of ethanol. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alcohol Elsevier

Volitional consumption of ethanol by fawn-hooded rats: Effects of alternative solutions and drug treatments

Alcohol, Volume 12 (4) – Jul 1, 1995

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0741-8329
DOI
10.1016/0741-8329(95)00015-J
Publisher site
See Article on Publisher Site

Abstract

Behavioral and neurochemical measures of brain 5-hydroxytryptamine (5-HT) function in the Fawn-Hooded rat are abnormal relative to outbred strains of rats. Fawn-Hooded rats freely drink large amounts of 10% ethanol in the presence of water and have been proposed to be an animal model for studies related to alcoholism. In this study, Fawn-Hooded rats were given solutions of ethanol increasing in concentration from 3% to 30% (w/v in tap water) over 10 days with tap water in a second drinking tube and a third tube left empty. The solutions of ethanol that produced maximal drinking with a preference (ml ethanol/ml total fluid) near 50% ranged from 5% to 13%, which became: the fixed individual concentrations for each rat. After a 5-day baseline period the rats were offered a solution in the third drinking tube of either 0.5% aspartame or chocolate Ultra SlimFast (diluted with water 2: 1). The chocolate drink, but not aspartame, significantly reduced the consumption of alcohol by 73%. For the drug experiments, the rats were given successive 4-day periods of: baseline drinking; drug or saline injections b.i.d.; and a posttreatment period. Neither ipsapirone, a 5-HT 1a partial agonist, nor naltrexone injected inhibited the intakes of ethanol solutions. Treatment with 2.5 mg/kg of amperozide, a 5-HT 2 antagonist, decreased the consumption of ethanol by 38%, but also caused a decrease in consumption of food. These results show a pattern of drinking of increasing concentrations of ethanol different than other strains of rats. Because ethanol intakes of the Fawn-Hooded rat decline precipitously when offered palatable chocolate drink and fail to respond to drugs known to decrease human ethanol intake, this strain may not be a valid model for testing the effects of centrally acting drugs on the consumption of ethanol.

Journal

AlcoholElsevier

Published: Jul 1, 1995

References

  • Brain tryptophan metabolism in the 5-hydroxytryptamine and kynurenine pathways in a strain of rats with a deficiency in platelet 5-HT
    Joseph, M.H.
  • N-Alkyl-substituted aryl-piperazine drugs: Relationship between affinity for serotonin receptors and inhibition of aggression
    McMillen, B.A.; DaVanzo, E.A.; Scott, S.M.; Song, A.H.
  • Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains
    Overstreet, D.H.; Kampov-Polevoy, A.B.; Rezvani, A.H.; Murrelle, L.; Halikas, J.A.; Janowsky, D.S.
  • Ipsapirone and 8-OH-DPAT reduce ethanol preference in rats: Involvement of presynaptic 5-HT 1a receptors
    Schreiber, R.; Opitz, K.; Glaser, T.; De Vry, J.
  • Fawn hooded rats are subsensitive to the food intake suppressant effects of 5-HT agonists
    Wang, P.; Aulakh, C.S.; Hill, J.L.; Murphy, D.L.

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