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Vitamin B 12 and recurrent aphthous stomatitis

Dear editor, We appreciate Dr Bubirova's letter; however, we think there are a few things that need to be stressed more. Our article clearly stated that the exact cause of recurrent apthous stomatitis is still unknown. We do not agree with Dr Bubirova that all of our vitamin B 12 –deficient patients must be expected as having megaloblastic anemia. Referring to Table 1 in the article, one can see that the mean values of the vitamin B 12 levels were close to each other and that the levels were not low enough to cause overt anemia. In addition, our laboratory results are definitely reliable based on the external quality results that are regularly being checked by the Bio-Rad External Quality Assurance Program.</P>The second point that Dr Bubirova asked was of MCV levels. Although there was a statistically significant relationship between MCV levels and RAS occurrence, (binary logistic regression, P = .041), we purposely did not give the results so as to not confuse the readers about the hematologic parameters.</P>As stated in our article, we definitely believe that serum vitamin B 12 levels are closely related to RAS occurrence and that serum vitamin B 12 level is one of the tests that must be performed for every RAS patient.</P> http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Otolaryngology Elsevier

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