Ventral striatal and medial prefrontal BOLD activation is correlated with reward-related electrocortical activity: A combined ERP and fMRI study

Ventral striatal and medial prefrontal BOLD activation is correlated with reward-related... Functional magnetic resonance imaging (fMRI) research suggests that the ventral striatum (VS)/nucleus accumbens, medial prefrontal cortex (mPFC), and broader mesocorticolimbic dopamine system mediate aspects of reward processing from expectation of reward to pleasantness experienced upon reward attainment. In parallel, research utilizing event-related potentials (ERP) indicates that the feedback negativity (FN) is sensitive to reward vs. non-reward feedback and outcome expectation. The FN has been source localized to the mPFC and dorsal striatum, and converging evidence suggests that the FN reflects reward processing in the mesocorticolimbic system. However, the extent to which ERP and fMRI measures of reward processing are correlated has yet to be explored within the same individuals. The primary aim of the current study was to examine the convergence between fMRI (i.e., VS and mPFC) and ERP (i.e., FN) measures of reward processing in forty-two participants who completed counterbalanced fMRI and ERP sessions while performing the same monetary gambling task. For the Win > Loss comparison, fMRI activation in the mesocorticolimbic reward circuit including the VS and mPFC was positively correlated with the FN. Here, we demonstrate that monetary gains activate the VS, mPFC, caudate, amygdala, and orbital frontal cortex, enhance the FN ERP component within 300 ms post feedback, and that these measures are related. Thus, fMRI and ERP measures provide complementary information about mesocorticolimbic activity during reward processing, which may be useful in assessing pathological reward sensitivity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroimage Elsevier

Ventral striatal and medial prefrontal BOLD activation is correlated with reward-related electrocortical activity: A combined ERP and fMRI study

Loading next page...
 
/lp/elsevier/ventral-striatal-and-medial-prefrontal-bold-activation-is-correlated-2QdHZXKZhr
Publisher
Elsevier
Copyright
Copyright © 2011 Elsevier Inc.
ISSN
1053-8119
eISSN
1095-9572
D.O.I.
10.1016/j.neuroimage.2011.05.037
Publisher site
See Article on Publisher Site

Abstract

Functional magnetic resonance imaging (fMRI) research suggests that the ventral striatum (VS)/nucleus accumbens, medial prefrontal cortex (mPFC), and broader mesocorticolimbic dopamine system mediate aspects of reward processing from expectation of reward to pleasantness experienced upon reward attainment. In parallel, research utilizing event-related potentials (ERP) indicates that the feedback negativity (FN) is sensitive to reward vs. non-reward feedback and outcome expectation. The FN has been source localized to the mPFC and dorsal striatum, and converging evidence suggests that the FN reflects reward processing in the mesocorticolimbic system. However, the extent to which ERP and fMRI measures of reward processing are correlated has yet to be explored within the same individuals. The primary aim of the current study was to examine the convergence between fMRI (i.e., VS and mPFC) and ERP (i.e., FN) measures of reward processing in forty-two participants who completed counterbalanced fMRI and ERP sessions while performing the same monetary gambling task. For the Win > Loss comparison, fMRI activation in the mesocorticolimbic reward circuit including the VS and mPFC was positively correlated with the FN. Here, we demonstrate that monetary gains activate the VS, mPFC, caudate, amygdala, and orbital frontal cortex, enhance the FN ERP component within 300 ms post feedback, and that these measures are related. Thus, fMRI and ERP measures provide complementary information about mesocorticolimbic activity during reward processing, which may be useful in assessing pathological reward sensitivity.

Journal

NeuroimageElsevier

Published: Aug 15, 2011

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off