Vasopressinergic regulation of the hypothalamic–pituitary–adrenal axis: implications for stress adaptation

Vasopressinergic regulation of the hypothalamic–pituitary–adrenal axis: implications for... In addition to its role on water conservation, vasopressin (VP) regulates pituitary ACTH secretion by potentiating the stimulatory effects of corticotropin releasing hormone (CRH). The pituitary actions of VP are mediated by plasma membrane receptors of the V1b subtype, coupled to calcium–phospholipid signaling systems. VP is critical for adaptation of the hypothalamic–pituitary–adrenal (HPA) axis to stress as indicated by preferential expression of VP over CRH in parvocellular neurons of the hypothalamic paraventricular nucleus, and the upregulation of pituitary VP receptors during stress paradigms associated with corticotroph hyperresponsiveness. V1b receptor mRNA levels and coupling of the receptor to phospolipase C are stimulated by glucocorticoids, effects which may contribute to the refractoriness of VP-stimulated ACTH secretion to glucocorticoid feedback. The data suggest that vasopressinergic regulation of the HPA axis is critical for sustaining corticotroph responsiveness in the presence of high circulating glucocorticoid levels during chronic stress. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Regulatory Peptides Elsevier

Vasopressinergic regulation of the hypothalamic–pituitary–adrenal axis: implications for stress adaptation

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Publisher
Elsevier
Copyright
Copyright © 2000 Elsevier Ltd
ISSN
0167-0115
eISSN
1873-1686
DOI
10.1016/S0167-0115(00)00196-8
Publisher site
See Article on Publisher Site

Abstract

In addition to its role on water conservation, vasopressin (VP) regulates pituitary ACTH secretion by potentiating the stimulatory effects of corticotropin releasing hormone (CRH). The pituitary actions of VP are mediated by plasma membrane receptors of the V1b subtype, coupled to calcium–phospholipid signaling systems. VP is critical for adaptation of the hypothalamic–pituitary–adrenal (HPA) axis to stress as indicated by preferential expression of VP over CRH in parvocellular neurons of the hypothalamic paraventricular nucleus, and the upregulation of pituitary VP receptors during stress paradigms associated with corticotroph hyperresponsiveness. V1b receptor mRNA levels and coupling of the receptor to phospolipase C are stimulated by glucocorticoids, effects which may contribute to the refractoriness of VP-stimulated ACTH secretion to glucocorticoid feedback. The data suggest that vasopressinergic regulation of the HPA axis is critical for sustaining corticotroph responsiveness in the presence of high circulating glucocorticoid levels during chronic stress.

Journal

Regulatory PeptidesElsevier

Published: Dec 22, 2000

References

  • Regulation of pituitary vasopressin receptors during chronic stress: relationship with corticotroph responsiveness
    Aguilera, G.; Pham, Q.; Rabadan-Diehl, C.
  • Regulation of pituitary vasopressin V1b receptor mRNA during stress in the rat
    Rabadan-Diehl, C.; Lolait, S.J.; Aguilera, G.
  • Pathways to the secretion of adrenocorticotropin: view from the portal
    Plotsky, P.M.
  • Rapid changes of heteronuclear RNA for arginine vasopressin but not for corticotropin releasing hormone in response to acute corticosterone administration
    Ma, X.-M.; Levy, A.; Lightman, S.L.
  • CRF stimulates expression of multiple fos and jun related genes in the AtT-20 corticotroph cell
    Autelitano, D.J.; Cohen, D.R.

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