The introduction of vaccination remains one of the major breakthroughs in the development of modern medical practice; their use has provided protection from numerous life-threatening diseases and significantly reduced mortality and morbidity in people of all ages. Edward Jenner, the father of vaccination, is in fact one of the heroes of modern medicine. Yet, there is increasing concern that the widespread use of vaccines has led to unanticipated and occasional severe reactions  . The statistics on vaccination frequency are themselves overwhelming; for example in the United States and within just the first 6 years of life children are administered between 9 and 12 different vaccine doses. While it is not unusual for local complications such as swelling, pain, or fever to occur, the increased frequency of vaccinations makes it nearly impossible to determine whether, similar to natural infections, some vaccines might induce autoimmunity in genetically susceptible hosts  . There remain very little hard data to support a 100% safety assertion. On the other hand, there are significant observations that warn of the consequences should vaccination practice be curtailed or even stopped. This does not imply, however, that there should not be rigorous studies to assess whether
Autoimmunity Reviews – Elsevier
Published: Feb 1, 2005
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