Use of the Filovirus Animal Non-Clinical Group (FANG) Ebola virus immuno-assay requires fewer study participants to power a study than the Alpha Diagnostic International assay

Use of the Filovirus Animal Non-Clinical Group (FANG) Ebola virus immuno-assay requires fewer... •Performance of two ELISAs to detect IgG against EBOV glycoprotein were compared.•The Alpha Diagnostic International (ADI) assay is commercially available.•The Filovirus Animal Nonclinical Group (FANG) assay is seeking FDA approval.•The FANG assay has lower study power requirements than the ADI assay.•We optimized the ADI assay by applying key methods from the FANG assay. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Virological Methods Elsevier

Use of the Filovirus Animal Non-Clinical Group (FANG) Ebola virus immuno-assay requires fewer study participants to power a study than the Alpha Diagnostic International assay

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Publisher
Elsevier
Copyright
Copyright © 2018 The Authors
ISSN
0166-0934
eISSN
1879-0984
D.O.I.
10.1016/j.jviromet.2018.02.018
Publisher site
See Article on Publisher Site

Abstract

•Performance of two ELISAs to detect IgG against EBOV glycoprotein were compared.•The Alpha Diagnostic International (ADI) assay is commercially available.•The Filovirus Animal Nonclinical Group (FANG) assay is seeking FDA approval.•The FANG assay has lower study power requirements than the ADI assay.•We optimized the ADI assay by applying key methods from the FANG assay.

Journal

Journal of Virological MethodsElsevier

Published: May 1, 2018

References

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