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Urine but not plasma nitric oxide metabolites are decreased in women with preeclampsia

Urine but not plasma nitric oxide metabolites are decreased in women with preeclampsia OBJECTIVE: Nitric oxide is a potent vasorelaxant produced by endothelial cells. We tested the hypothesis that urinary and perhaps plasma nitric oxide metabolites would be reduced in women with preeclampsia. STUDY DESIGN: Plasma and urine from 14 women meeting strict clinical criteria for the diagnosis of preeclampsia and 20 normal nulliparous women were assayed for the stable metabolites of nitric oxide, nitrate and nitrite. RESULTS: There was no significant difference of plasma concentrations of nitrate and nitrite between women with preeclampsia and women with normal pregnancies (32.7 ± 3.1 vs 25.8 ± 2.4 μmol/L). Plasma creatinine levels were elevated in women with preeclampsia (0.85 ± 0.09 vs 0.66 ± 0.02 mg/dl, p < 0.01), indicating a reduced glomerular filtration rate. Urine concentrations of nitrate and nitrite normalized by creatinine excretion were significantly lower in women with preeclampsia compared with normal pregnant women (0.37 ± 0.06 vs 0.69 ± 0.11 μmol of nitrite per milligram creatinine, p < 0.05). CONCLUSIONS: Our study using concomitant measurement of plasma and urine nitrate and nitrite suggests a reduced production of nitric oxide in women with preeclampsia compared with normal pregnant women. (AM J OBSTET GYNECOL 1996;174:1008-13.) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Obstetrics and Gynecology Wolters Kluwer Health

Urine but not plasma nitric oxide metabolites are decreased in women with preeclampsia

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Publisher
Wolters Kluwer Health
Copyright
Copyright © 1996 Mosby, Inc.
ISSN
0002-9378
DOI
10.1016/S0002-9378(96)70341-1
Publisher site
See Article on Publisher Site

Abstract

OBJECTIVE: Nitric oxide is a potent vasorelaxant produced by endothelial cells. We tested the hypothesis that urinary and perhaps plasma nitric oxide metabolites would be reduced in women with preeclampsia. STUDY DESIGN: Plasma and urine from 14 women meeting strict clinical criteria for the diagnosis of preeclampsia and 20 normal nulliparous women were assayed for the stable metabolites of nitric oxide, nitrate and nitrite. RESULTS: There was no significant difference of plasma concentrations of nitrate and nitrite between women with preeclampsia and women with normal pregnancies (32.7 ± 3.1 vs 25.8 ± 2.4 μmol/L). Plasma creatinine levels were elevated in women with preeclampsia (0.85 ± 0.09 vs 0.66 ± 0.02 mg/dl, p < 0.01), indicating a reduced glomerular filtration rate. Urine concentrations of nitrate and nitrite normalized by creatinine excretion were significantly lower in women with preeclampsia compared with normal pregnant women (0.37 ± 0.06 vs 0.69 ± 0.11 μmol of nitrite per milligram creatinine, p < 0.05). CONCLUSIONS: Our study using concomitant measurement of plasma and urine nitrate and nitrite suggests a reduced production of nitric oxide in women with preeclampsia compared with normal pregnant women. (AM J OBSTET GYNECOL 1996;174:1008-13.)

Journal

American Journal of Obstetrics and Gynecology – Wolters Kluwer Health

Published: Mar 1, 1996

References

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