•I.p. injected uric acid (UA) increased the number of spike-wave discharges (SWDs).•Allopurinol also elevated the SWD number in Wistar Albino Glaxo/Rijswijk/WAG/Rij rats.•Injection of allopurinol with inosine and inosine with UA enhanced the SWD number.•Application of indomethacin with UA abolished the UA-evoked increase in SWD number.•Both uric acid and allopurinol have proepileptic effects at least in WAG/Rij rats.
Brain Research – Elsevier
Published: May 1, 2018
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