Unusual incidence of aplastic anaemia due to B-19 parvovirus infection in renal transplant recipients

Unusual incidence of aplastic anaemia due to B-19 parvovirus infection in renal transplant... ELSEVIER E. Bertoni, A. Rosati, M. Zanazzi, A. Azzi, K. Zakrewska, S. Guidi, and M. Salvadori ARVOVIRUS B-19, a recently discovered singlestranded DNA virus, has been identified as the aetiological agent of “fifth disease” in childhood and of transient aplastic anaemia crisis in patients with haemolytic anaemia.‘ ** It is also a known cause of chronic anaemia in immunocompromised hosts affected by AIDS, lymphocytic leukemia3 or in organ transplant recipients.4-6 B-19 infects, replicates in, and then lyses erythroid progenitor cells. The B-19 virus receptor has been identified as the blood group P antigen that can be found on the erythroblast and megakaryoblast surfaces. PATIENTS AND METHODS Table 1. Parvovirus affected vs unaffected patients Affected Sex Age Day post p.o. S. Cr. (mg/dL) Hb (g/dL) Ret. (%) Not Affected AZA (Y/N) 2F 2M 53 % 4.24 22.5 ? 9.7 1.5 + 0.35 6.56 + 0.6 0.32 ? 0.3 lY3N 3F 42.6 121.4 1.32 8.9 1.32 5Y 2M ? 11 + 88.3 2 0.22 + 0.4 + 0.4 ON P P P P P P P = = = = < < i NS NS .05 NS ,001 ,005 .005 On 3/94 we found a severe anaemia in a cadaveric http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transplantation Proceedings Elsevier

Unusual incidence of aplastic anaemia due to B-19 parvovirus infection in renal transplant recipients

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Abstract

ELSEVIER E. Bertoni, A. Rosati, M. Zanazzi, A. Azzi, K. Zakrewska, S. Guidi, and M. Salvadori ARVOVIRUS B-19, a recently discovered singlestranded DNA virus, has been identified as the aetiological agent of “fifth disease” in childhood and of transient aplastic anaemia crisis in patients with haemolytic anaemia.‘ ** It is also a known cause of chronic anaemia in immunocompromised hosts affected by AIDS, lymphocytic leukemia3 or in organ transplant recipients.4-6 B-19 infects, replicates in, and then lyses erythroid progenitor cells. The B-19 virus receptor has been identified as the blood group P antigen that can be found on the erythroblast and megakaryoblast surfaces. PATIENTS AND METHODS Table 1. Parvovirus affected vs unaffected patients Affected Sex Age Day post p.o. S. Cr. (mg/dL) Hb (g/dL) Ret. (%) Not Affected AZA (Y/N) 2F 2M 53 % 4.24 22.5 ? 9.7 1.5 + 0.35 6.56 + 0.6 0.32 ? 0.3 lY3N 3F 42.6 121.4 1.32 8.9 1.32 5Y 2M ? 11 + 88.3 2 0.22 + 0.4 + 0.4 ON P P P P P P P = = = = < < i NS NS .05 NS ,001 ,005 .005 On 3/94 we found a severe anaemia in a cadaveric

Journal

Transplantation ProceedingsElsevier

Published: Feb 1, 1997

References

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