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release (reviewed in Niccolini et al., 2014). A study of the lesioning effects of 6 - hydroxydopamine ( 6 -OHDA, used in modelling Parkinson’s disease in animals) on D1 and D2 receptor availability in the rat ...
://www.taconic.com) provided adult female Sprague-Dawley rats (170–190 g) with unilateral 6 -hydroxy- dopamine ( 6 -OHDA) lesions . A total of 8 μg of 6 -OHDA was infused in 4 μl over 4 minutes into the nigrostriatal ...
Abstract We show that human embryonic stem cell-derived dopaminergic neurons survived transplantation to the neurotoxin 6 - hydroxydopamine - lesioned rat striatum and, in combination with the cells ...
the neurophysiological changes taking place in the cerebello–cortical circuit in PD, using a rodent model of the disease using the 6 -OHDA ( 6 - hydroxydopamine ) toxin to lesion mesostriatal dopaminergic neurons ...
to survive, partially innervate the striatum of 6 - hydroxydopamine ( 6 -OHDA) lesioned rodents or primates, and ameliorate motor function via neuronal integration [4, 5, 7 20139]. Although these new protocols ...
that MPTP crosses the blood-brain barrier (BBB), to be metabolized in astrocytes to its active metabolite (1-methyl-4-phenylpyridinium, MPP+), and to enter catecholamine neurons through the dopamine ...
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