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Umbilical cord plasma homocysteine concentrations are elevated at delivery in pregnancies complicated by preeclampsia

Umbilical cord plasma homocysteine concentrations are elevated at delivery in pregnancies... <h5>Objective</h5> Elevated serum homocysteine levels have been found in women destined to develop preeclampsia. Fetal cord homocysteine levels directly correlate with maternal serum levels in normal pregnancies. We hypothesize that fetuses from women with preeclampsia may also have elevated plasma homocysteine levels, which if true, may contribute to the increased fetal morbidity found in these pregnancies. Our objective was to determine if umbilical cord plasma of neonates born to mothers with preeclampsia have elevated homocysteine levels.</P><h5>Study design</h5> Maternal blood samples were collected at time of admission for labor in normotensive uncomplicated pregnancies and likewise in pregnancies complicated by preeclampsia at term. Umbilical cord blood samples were collected from these same pregnancies at the time of delivery. Plasma was extracted from these samples and stored at −70°C. Samples were analyzed in batch for homocysteine using the ADVIA Centaur HCY assay. A Student's t-test was used for statistical analysis. All results are reported in as means ± SD.</P><h5>Results</h5> Ten paired maternal and umbilical cord plasma samples were obtained from normotensive pregnancies. Eight similar paired samples were obtained from pregnancies complicated by preeclampsia. Homocysteine concentrations in maternal plasma in pregnancies complicated by preeclampsia were significantly higher compared to those in normotensive http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Obstetrics and Gynecology Wolters Kluwer Health

Umbilical cord plasma homocysteine concentrations are elevated at delivery in pregnancies complicated by preeclampsia

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Publisher
Wolters Kluwer Health
Copyright
Copyright © 2004 Elsevier Inc.
ISSN
0002-9378
DOI
10.1016/j.ajog.2004.10.015
Publisher site
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Abstract

<h5>Objective</h5> Elevated serum homocysteine levels have been found in women destined to develop preeclampsia. Fetal cord homocysteine levels directly correlate with maternal serum levels in normal pregnancies. We hypothesize that fetuses from women with preeclampsia may also have elevated plasma homocysteine levels, which if true, may contribute to the increased fetal morbidity found in these pregnancies. Our objective was to determine if umbilical cord plasma of neonates born to mothers with preeclampsia have elevated homocysteine levels.</P><h5>Study design</h5> Maternal blood samples were collected at time of admission for labor in normotensive uncomplicated pregnancies and likewise in pregnancies complicated by preeclampsia at term. Umbilical cord blood samples were collected from these same pregnancies at the time of delivery. Plasma was extracted from these samples and stored at −70°C. Samples were analyzed in batch for homocysteine using the ADVIA Centaur HCY assay. A Student's t-test was used for statistical analysis. All results are reported in as means ± SD.</P><h5>Results</h5> Ten paired maternal and umbilical cord plasma samples were obtained from normotensive pregnancies. Eight similar paired samples were obtained from pregnancies complicated by preeclampsia. Homocysteine concentrations in maternal plasma in pregnancies complicated by preeclampsia were significantly higher compared to those in normotensive

Journal

American Journal of Obstetrics and Gynecology – Wolters Kluwer Health

Published: Dec 1, 2004

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