Introduction</h5> Synthesis of biologically active heterocyclic compounds is a thrust area in organic chemistry research worldwide and their syntheses have widely been explored [1–4] . In the broad class of heterocyclic systems, 4 H -pyrans and their derivatives possess a unique importance in medicinal and biological chemistry [5,6] . The 4 H -pyran were found to exhibit anti-proliferative, cancer chemopreventive, antimyopic, antirheumatic, anti-bacterial, hypotensive, and antiasthmatic activities [7–14] .</P>Among the important 4 H -pyran heterocyclic compounds, 2-amino-chromenes are widely used as pigments, potential agrochemicals, cosmetics, and represent an important class of chemical entities being the main constituents of many natural products [15–17] . Among various types of chromene systems, 2-amino-4 H -chromenes are of particular utility as they belong to privileged medicinal scaffolds serving for generation of small-molecule ligands with highly pronounced anticoagulant, diuretic, spasmolitic and antianaphylactic activities [18–23] . Moreover, the current interest in 2-amino-4 H -chromenes arises from their potential application in the treatment of human inflammatory TNFα-mediated diseases, such as psoriatic arthritis and rheumatoid and in cancer therapy [24–26] .</P>In view of these useful properties, various procedures have been focused on the development of environmentally friendly methodologies to synthesize 2-amino-4 H -chromene heterocyclics by cyclization
Journal of Molecular Structure – Elsevier
Published: Aug 25, 2014
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