Ubiquitin: structures, functions, mechanisms

Ubiquitin: structures, functions, mechanisms Ubiquitin is the founding member of a family of structurally conserved proteins that regulate a host of processes in eukaryotic cells. Ubiquitin and its relatives carry out their functions through covalent attachment to other cellular proteins, thereby changing the stability, localization, or activity of the target protein. This article reviews the basic biochemistry of these protein conjugation reactions, focusing on ubiquitin itself and emphasizing recent insights into mechanism and specificity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Elsevier

Ubiquitin: structures, functions, mechanisms

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Publisher
Elsevier
Copyright
Copyright © 2004 Elsevier B.V.
ISSN
0167-4889
D.O.I.
10.1016/j.bbamcr.2004.09.019
Publisher site
See Article on Publisher Site

Abstract

Ubiquitin is the founding member of a family of structurally conserved proteins that regulate a host of processes in eukaryotic cells. Ubiquitin and its relatives carry out their functions through covalent attachment to other cellular proteins, thereby changing the stability, localization, or activity of the target protein. This article reviews the basic biochemistry of these protein conjugation reactions, focusing on ubiquitin itself and emphasizing recent insights into mechanism and specificity.

Journal

Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchElsevier

Published: Nov 29, 2004

References

  • Structural properties of polyubiquitin chains in solution
    Varadan, R.; Walker, O.; Pickart, C.M.; Fushman, D.
  • Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation
    Sarcevic, B.; Mawson, A.; Baker, R.T.; Sutherland, R.L.
  • Structural basis of ubiquitylation
    VanDemark, A.P.; Hill, C.P.
  • Characterization of the binding interface between ubiquitin and class I human ubiquitin-conjugating enzyme 2b by multidimensional heteronuclear NMR spectroscopy in solution
    Miura, T.; Klaus, W.; Gsell, B.; Miyamoto, C.; Senn, H.
  • The E2–E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain
    Xie, Y.; Varshavsky, A.
  • Identification of a ubiquitin-protein ligase subunit within the CCR4–NOT transcription repressor complex
    Albert, T.K.; Hanzawa, H.; Legtenberg, Y.I.A.; van den Heuvel, F.A.J.; Collart, M.A.; Boelens, R.; Timmers, H.T.M.
  • NEDD8 recruits E2-ubiquitin to SCF E3 ligase
    Kawakami, T.; Chiba, T.; Suzuki, T.; Iwai, K.; Yamanaka, K.; Minato, N.; Suzuki, H.; Shimbara, N.; Hidaka, Y.; Osaka, F.; Omata, M.; Tanaka, K.
  • Structure of the PHD zinc finger from human Williams–Beuren Syndrome transcription factor
    Pascual, J.; Martinez-Yamout, M.; Dyson, H.J.; Wright, P.E.
  • Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains
    Capili, A.D.; Schultz, D.C.; Rauscher, F.J.; Borden, K.L.B.
  • A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition
    Coscoy, L.; Sanchez, D.J.; Ganem, D.
  • Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation
    Hewitt, E.W.; Duncan, L.; Mufti, D.; Baker, J.; Stevenson, P.G.; Lehner, P.J.
  • CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein
    Murata, S.; Minami, Y.; Minami, M.; Chiba, T.; Tanaka, K.
  • The von Hippel–Lindau tumor suppressor protein: new insights into oxygen sensing and cancer
    Kim, W.; Kaelin, W.G.
  • Mathematical modeling suggests cooperative interactions between a disordered polyvalent ligand and a receptor site
    Klein, P.; Pawson, T.; Tyers, M.
  • Structure determination of the small ubiquitin-related modifier Sumo-1
    Bayer, P.; Arndt, A.; Metzger, S.; Mahajan, R.; Melchior, F.; Jaenicke, R.; Becker, J.
  • MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
    Kraulis, P.J.

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