Two distinctive antinociceptive systems in rats with pathological pain

Two distinctive antinociceptive systems in rats with pathological pain A common obstacle in clinical management of pathological pain is the poor response to opioid analgesics. We now report that Δ 9 -tetrahydrocannabinol (Δ 9 -THC)-induced antinociception remained effective in rats with pathological pain. The selective central cannabinoid receptor antagonist SR141716A, but not the generic opioid receptor antagonist naloxone, blocked the Δ 9 -THC antinociception. Moreover, there is no cross-tolerance between the antinociceptive effects of morphine and Δ 9 -THC in pathological pain states. The results indicate that Δ 9 -THC antinociception is both effective and independent of opioid receptors in rats with pathological pain. Thus, the cannabinoid analgesic system may be superior to opioids in alleviating intractable pathological pain syndromes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

Two distinctive antinociceptive systems in rats with pathological pain

Neuroscience Letters, Volume 280 (1) – Feb 11, 2000

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Publisher
Elsevier
Copyright
Copyright © 2000 Elsevier Science Ireland Ltd
ISSN
0304-3940
D.O.I.
10.1016/S0304-3940(99)00998-2
Publisher site
See Article on Publisher Site

Abstract

A common obstacle in clinical management of pathological pain is the poor response to opioid analgesics. We now report that Δ 9 -tetrahydrocannabinol (Δ 9 -THC)-induced antinociception remained effective in rats with pathological pain. The selective central cannabinoid receptor antagonist SR141716A, but not the generic opioid receptor antagonist naloxone, blocked the Δ 9 -THC antinociception. Moreover, there is no cross-tolerance between the antinociceptive effects of morphine and Δ 9 -THC in pathological pain states. The results indicate that Δ 9 -THC antinociception is both effective and independent of opioid receptors in rats with pathological pain. Thus, the cannabinoid analgesic system may be superior to opioids in alleviating intractable pathological pain syndromes.

Journal

Neuroscience LettersElsevier

Published: Feb 11, 2000

References

  • The analgesic effect of R(+)-Win 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain
    Herzberg, U.; Eliav, E.; Bennett, G.J.; Kopin, I.J.
  • The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive
    Ossipov, M.H.; Lopez, Y.; Nichols, M.L.; Bian, D.; Porreca, F.

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