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that such tumor specific acidic environment can be exploited for the development of therapeutic strategies against cancer. Independent observations show reduction in pH of mammalian cells undergoing ...
, leading to a low target-to-background signal ratio, results in low imaging resolution and accuracy. Tumor environment - specific activatable multifunctional contrast agents need to maximize the contrast ...
lower. Unlike hematological malignancies, solid tumors generate environments that suppress antitumor immunity. In particular, low pH , limited oxygen, and the presence of suppressive cytokines (e.g., TGF‐β ...
, we exploit the acidic tumor micro- environment to selectively deliver antigenic peptides to cancer using pH ( low ) insertion peptides (pHLIP). We demonstrated the delivery of MHC binding peptides directly ...
that the ADR release from the pH ‐sensitive polymeric micelles is significantly faster at pH 5.0 than at of pH 7.4. The tetrazolium dye method (MTT assay) shows that all the conjugate@IO exhibit low cytotoxicity ...
Methotrexate (MTX) is a well-known chemotherapeutic agent for solid tumor . However, its clinical usage is limited due to low permeability, cellular drug efflux, and non- specific drug delivery ...
switch to positive charge in low - pH environment , which was in favor of cellular uptake due to the strengthened positive nanocarrier–negative cellular membrane interaction. Once internalized into tumor ...
cancer (HepG2), and normal cell lines was investigated. Alizarin 2-O-methoxide showed an inhibitory effect on all three cancer-cell lines at very low concentrations, from 0.078 µM, with no cytotoxicity ...
system can be obtained, which is fairly stable in the aqueous environment at a pH of above 6.5, while the acidity of the tumor microenvironment and endosomes protonates the poly(l-His) “core” and increases ...
lines (Fig. 3A) but had less effect on EGFR low -expressing cell lines (Fig. 3B). AGT exhibited an enhanced at least 500-folds cytotoxicity in four of five EGFR high-expressing tumor cell lines. However ...
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