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and maintenance of peripheral nerve function. We have established conditions by which human induced pluripotent stem cell-derived sensory neurons can be cultured with rat Schwann cells, and have produced ...
). Materials and Methods Primary DRG neuron culture DRG were harvested from embryonic d 15 Sprague Dawley rats , dissociated in 1% trypsin, and then cultured on rat -tail collagen-coated culture plates in growth ...
to decrease as the animal ages (Wilson and Raisman 1980; Weiler and Farbman 1997, 1998a,b; Weiler et al. 1999b). For example, while estimates vary, adult olfactory sensory neurons are generally reported to have ...
the assessment of agents that functionally impair sensory neurons . Cell-based model systems for the PNS are still mostly based on non-human cells, like rat dorsal root ganglion (DRG) neurons . Such DRG cultures ...
and scaled to the peak Na+ current contaminating the PSCs. Short - Term Plasticity To analyze the paired-pulse ratio (PPR), 2 brief depolarizing pulses were applied to autaptic neurons with variable interpulse ...
the effects of AEDs on vertebrate aging , one interesting study was conducted with phenytoin, an AED with a structure similar to that of ethosuximide.Long- term treatment with phenytoin in a small group of female ...
= 7 per group. https://doi.org/10.1371/journal.pone.0266331.g001 GTDE improved the short - term memory of d-gal-induced aging rats Both the familiar/novel object recognition test and familiar/novel ...
Abstract Context Nerve growth factor is a neurotrophic factor that promotes the survival of small fiber sensory neurons and sympathetic neurons in the peripheral nervous system. Recombinant human ...
active cultures . This led us to analyze the period of short - term recovery more closely with in situ hybridization. Compared to active OTCs (Fig. 7A), only very few neurons had remained above detection ...
Introduction Spiral ganglion neurons convey sensory information from the hair cells of the cochlea to the brain stem and are vulnerable to damage from noise, aging , and underlying genetic diseases ...
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