Transepithelial Transport of Oligopeptides in the Human Intestinal Cell, Caco-2

Transepithelial Transport of Oligopeptides in the Human Intestinal Cell, Caco-2 Shimizu, M., M. Tsunogai, S. Arai. Transepithelial transport of oligopeptides in the human intestinal cell, Caco-2. Peptides 18(5) 681-687, 1997.—The transepithelial transport of oligopeptides (of more than 4 residues) was studied by using human intestinal Caco-2 cell monolyers. The susceptibility to the brush-border peptidases was observed to be one of the primary factors which decide the transport rate. The apical-to-basolateral transport mechanism was investigated by using bradykinin and GGYR which were resistant to cellular peptidases. The intracellular pathway, probably the adsorptive transcytosis, was suggested to be involved in the transport of bradykinin and its analogues, the transport rate being particularly dependent on the hydrophobic properties of the peptides. On the other hand, the tetrapeptide such as GGYR was suggested to be transported mainly via the paracellular pathway. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Peptides Elsevier

Transepithelial Transport of Oligopeptides in the Human Intestinal Cell, Caco-2

Peptides, Volume 18 (5) – Jan 1, 1997

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Publisher
Elsevier
Copyright
Copyright © 1997 Elsevier Science Inc.
ISSN
0196-9781
D.O.I.
10.1016/S0196-9781(97)00002-8
Publisher site
See Article on Publisher Site

Abstract

Shimizu, M., M. Tsunogai, S. Arai. Transepithelial transport of oligopeptides in the human intestinal cell, Caco-2. Peptides 18(5) 681-687, 1997.—The transepithelial transport of oligopeptides (of more than 4 residues) was studied by using human intestinal Caco-2 cell monolyers. The susceptibility to the brush-border peptidases was observed to be one of the primary factors which decide the transport rate. The apical-to-basolateral transport mechanism was investigated by using bradykinin and GGYR which were resistant to cellular peptidases. The intracellular pathway, probably the adsorptive transcytosis, was suggested to be involved in the transport of bradykinin and its analogues, the transport rate being particularly dependent on the hydrophobic properties of the peptides. On the other hand, the tetrapeptide such as GGYR was suggested to be transported mainly via the paracellular pathway.

Journal

PeptidesElsevier

Published: Jan 1, 1997

References

  • Quantitative approaches to delineate paracellular diffusion in cultured epithelial cell monolayers
    Adson, A.; Raub, T.J.; Burton, P.S.; Barsuhn, C.L.; Hilgers, A.R.; Audus, K.L.; Ho, N.F.H.
  • Gastrointestinal absorption of intact proteins
    Gardner, M.L.
  • Regulation of system y + arginine transport capacity in differentiating human intestinal Caco-2 cells
    Pan, M.; Malandro, A.; Stevens, B.R.
  • Dipeptide transporters in apical and basolateral membranes of the human intestinal cell line Caco-2
    Saito, H.; Inui, K.

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