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, and the expression of CyclinE, CDK2 and p-ERK1/2 was significantly down - regulated , when compared with IGFBP - 3 -overexpressed cells. Conclusions IGFBP - 3 can promote the proliferation, colony formation and G1/S phase ...
conditions (Fig. 4) consistent with transcriptional regulation . ActD treatment of hepatocytes also prevented the normoxia-dependent induction of IGFBP -4 mRNA (Fig. 3 ) and IGFBP -4 protein (Fig. 4), although ...
protein induces the expression of IGFBP - 3 (196), represses the transcription of IGF-II from its P3 and P4 promoters (33,197), and suppresses IGF-IR expression (70,198,199). Not only does p53 regulate ...
Immunofluorescence staining for the co-localization of IGFBP -1 and CSNK-2β and the co-localization of IGFBP -1 and CSNK-2β. Human hepatocellular carcinoma (HepG2) cells were stained with anti-mouse IGFBP - 1 (monoclonal ...
significantly down - regulated in tumors compared with the matched non-tumor tissues (Figure 2C; P < 0.05), while 3 genes showed insignificant changes (Supplementary Figure S2B). The overall screening strategies ...
and hepatocellular carcinoma. Biochem. Biophys. Res. Commun. , 282 , 647 –654. 34 Wu,C.G., Forgues,M., Siddique,S., Farnsworth,J., Valerie,K. and Wang,X.W. ( 2002 ) SAGE transcript profiles of normal primary human ...
with the IGF receptor (8). In the fetus, the liver is the primary source of circulating IGFBP -1 (9). Human IUGR is associated with increased IGFBP -1 levels and IGFBP -1 hyperphosphorylation in umbilical cord ...
accumbens associated protein-1 (NACC-1) has been evaluated in several cancers. This protein is a transcriptional regulator that regulates a number of significant cellular processes. In the current study, we ...
- regulated in GPC3-high samples relative to GPC3-low subgroup. (D). Genes down - regulated in HCC were also down - regulated in GPC3-high subgroup relative to GPC3-low controls (E). Figure 3 . Open in new ...
of apoptosis (anti-apoptosis, q < 10–4), angiogenesis (q < 10–4), inflammation (cellular response to lipopolysaccharide, q < 10–4), positive regulation of cell migration (q < 10– 3 ), and growth factor activity ...
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