Toxic effects of human pharmaceuticals to Folsomia candida – A multigeneration approach

Toxic effects of human pharmaceuticals to Folsomia candida – A multigeneration approach The study of the effects of human pharmaceuticals has been considered a priority in terms of environmental safety. However, the available information concerning soil organisms is scarce. To decrease this knowledge gap, the effects of carbamazepine and fluoxetine (0.04, 0.4, 4 and 40mg·kg−1 of soil) were assessed on the springtail Folsomia candida, for three consecutive generations. The assessed endpoints included survival, reproduction and biomarkers associated with biotransformation, neurotransmission and peroxidative damage. A light avoidance behavior test was performed, in the third generation. The obtained data demonstrate that both pharmaceuticals may affect Collembola populations after three generational exposures, as showed by the decrease trend for both survival and reproduction. The effects of carbamazepine were however, more pronounced. After the third generational exposure to all carbamazepine tested concentrations and the three highest concentrations of fluoxetine, F. candida displayed altered light avoidance behavior. The biochemical endpoints also revealed that carbamazepine and fluoxetine may exert toxic effects to F. candida through the induction of oxidative stress and impairment in neurotransmission with an apparent higher potential for carbamazepine. Overall, data show that the effects of pharmaceuticals throughout different generations should be considered in risk assessment studies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Science of the Total Environment Elsevier

Toxic effects of human pharmaceuticals to Folsomia candida – A multigeneration approach

Loading next page...
 
/lp/elsevier/toxic-effects-of-human-pharmaceuticals-to-folsomia-candida-a-i3oGlXEfb4
Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier B.V.
ISSN
0048-9697
eISSN
1879-1026
D.O.I.
10.1016/j.scitotenv.2017.12.319
Publisher site
See Article on Publisher Site

Abstract

The study of the effects of human pharmaceuticals has been considered a priority in terms of environmental safety. However, the available information concerning soil organisms is scarce. To decrease this knowledge gap, the effects of carbamazepine and fluoxetine (0.04, 0.4, 4 and 40mg·kg−1 of soil) were assessed on the springtail Folsomia candida, for three consecutive generations. The assessed endpoints included survival, reproduction and biomarkers associated with biotransformation, neurotransmission and peroxidative damage. A light avoidance behavior test was performed, in the third generation. The obtained data demonstrate that both pharmaceuticals may affect Collembola populations after three generational exposures, as showed by the decrease trend for both survival and reproduction. The effects of carbamazepine were however, more pronounced. After the third generational exposure to all carbamazepine tested concentrations and the three highest concentrations of fluoxetine, F. candida displayed altered light avoidance behavior. The biochemical endpoints also revealed that carbamazepine and fluoxetine may exert toxic effects to F. candida through the induction of oxidative stress and impairment in neurotransmission with an apparent higher potential for carbamazepine. Overall, data show that the effects of pharmaceuticals throughout different generations should be considered in risk assessment studies.

Journal

Science of the Total EnvironmentElsevier

Published: Jun 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off