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Introduction Type 2 diabetes mellitus (T2D) is a metabolic disease affecting more than 200 million people worldwide in 2010, and global prevalence is predicted to increase to more than 400 million ...
methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes . Diabetes . 2014; 63( 9): 2962– 2976. Google Scholar CrossRef Search ...
design to identify genetic and modifiable-environmental-lifestyle associated determinants of (1) epigenomic (DNA methylome) dysregulation of adipose DNL in type 2 diabetes mellitus (T2DM) adipose tissue ...
BACKGROUND Type 2 diabetes (T2D) is a complex disorder that is affected by multiple genetic and environmental factors. Extensive efforts have been made to identify the disease-affecting genes ...
), that hypermethylation occurs early in gastric carcinogenesis, and that hypermethylation uniformly affects a large CpG-rich region within the E-cadherin gene promoter. Materials and Methods Tumor tissues and control ...
functional consequences. In addition to slowing normal age- related changes, DR also causes hypermethylation in distinct regions of the genome. These DR- specific changes occurred predominantly in gene bodies ...
: Hypermethylation of the promoter region of the APC gene occurred in abnormal esophageal tissue in 48 (92%) of 52 patients with esophageal adenocarcinoma, in 16 (50%) of 32 patients with esophageal squamous cell ...
increasingly prevalent even in childhood, for unclear reasons. Overweight and obesity are probably the most important risk factors for the development of type 2 diabetes , the metabolic syndrome ...
that epigenetic mechanisms (heritable control of gene expression not related to DNA sequence), specifically DNA methylation, can be altered in placental tissue in the presence of maternal pathology. These studies ...
of Bmal1, or global deficiency of Cry1, impairs insulin sensitivity and glucose metabolism in mouse models ( 2 , 20). Moreover, clock gene expression is altered in peripheral blood cells from type 2 diabetic ...
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