Time dependent effect of chronic embryonic exposure to ethanol on zebrafish: Morphology, biochemical and anxiety alterations

Time dependent effect of chronic embryonic exposure to ethanol on zebrafish: Morphology,... •Chronic embryonic exposure to ethanol at low concentrations induced alteration in the spontaneous tail coiling, heart rate and mortality rate in zebrafish embryos.•Larvae received 0.75% continuous ethanol exposure exhibited decreased swimming activity while withdrawal ethanol exposure showed increased swimming activity as compared to the respective control.•This study also proved that ethanol had time dependent effect on anxiety related behavior, validated by the comparison with anxiogenic substance, caffeine.•The induction of apoptotic cell death and impairment in the biochemical profile cause by ethanol exposure during development may contributed to those impairment and alteration observed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Behavioural Brain Research Elsevier

Time dependent effect of chronic embryonic exposure to ethanol on zebrafish: Morphology, biochemical and anxiety alterations

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier B.V.
ISSN
0166-4328
D.O.I.
10.1016/j.bbr.2017.05.048
Publisher site
See Article on Publisher Site

Abstract

•Chronic embryonic exposure to ethanol at low concentrations induced alteration in the spontaneous tail coiling, heart rate and mortality rate in zebrafish embryos.•Larvae received 0.75% continuous ethanol exposure exhibited decreased swimming activity while withdrawal ethanol exposure showed increased swimming activity as compared to the respective control.•This study also proved that ethanol had time dependent effect on anxiety related behavior, validated by the comparison with anxiogenic substance, caffeine.•The induction of apoptotic cell death and impairment in the biochemical profile cause by ethanol exposure during development may contributed to those impairment and alteration observed.

Journal

Behavioural Brain ResearchElsevier

Published: Aug 14, 2017

References

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