•Transcriptional pattern of mTEC during the early phase of thymic involution was identified by RNA-seq.•Inflammation-related genes are upregulated and TNFα signaling is enhanced in mTEC during the early thymic involution.•Genes related to cell cycling and E2f3 target genes are downregulated in mTEC during the early phase of thymic involution.•Providing a conceptual framework for understanding the molecular mechanisms governing age-related degeneration of TEC.
Molecular Immunology – Elsevier
Published: Jul 1, 2018
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